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Title

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

AuthorsO’Hagan, Michael P.; Ramos-Soriano, Javier; Haldar, S.; Sheikh, Sadiyah; Morales, Juan C.; Mulholland, A.J.; Galan, M.Carmen
Issue Date2020
PublisherRoyal Society of Chemistry (UK)
CitationChemical Communications 56: 5186- 5189 (2020)
AbstractWe report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.
Publisher version (URL)http://dx.doi.org/10.1039/d0cc01581d
URIhttp://hdl.handle.net/10261/217772
DOIhttp://dx.doi.org/10.1039/d0cc01581d
Identifiersdoi: 10.1039/d0cc01581d
issn: 1359-7345
e-issn: 1364-548X
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