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Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

AuthorsCorkrum, M.; Covelo, A.; Lines, J.; Bellocchio, L.; Pisansky, M.; Loke, K.; Quintana, R.; Rothwell, P.E.; Luján, Rafael; Marsicano, G.; Martin, Eduardo D.; Thomas, M.J.; Kofuji, P.; Araque, Alfonso
synaptic transmission
nucleus accumbens
calcium imaging
brain reward system
Issue Date2020
PublisherCell Press
CitationNeuron 105: 1036- 1047.e5 (2020)
AbstractDopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using transgenic mice, optogenetics, and pharmacogenetics, we studied the role of astrocytes on the dopaminergic system. We show that in freely behaving mice, astrocytes in the nucleus accumbens (NAc), a key reward center in the brain, respond with Ca elevations to synaptically released dopamine, a phenomenon enhanced by amphetamine. In brain slices, synaptically released dopamine increases astrocyte Ca, stimulates ATP/adenosine release, and depresses excitatory synaptic transmission through activation of presynaptic A receptors. Amphetamine depresses neurotransmission through stimulation of astrocytes and the consequent A receptor activation. Furthermore, astrocytes modulate the acute behavioral psychomotor effects of amphetamine. Therefore, astrocytes mediate the dopamine- and amphetamine-induced synaptic regulation, revealing a novel cellular pathway in the brain reward system.Corkrum et al. report that astrocyte activity is required for dopamine- and amphetamine-evoked synaptic regulation and amphetamine-induced locomotor effects. Their study reveals astrocytes as active components of dopaminergic signaling and the brain reward system.
Publisher version (URL)http://dx.doi.org/10.1016/j.neuron.2019.12.026
Identifiersdoi: 10.1016/j.neuron.2019.12.026
issn: 1097-4199
Appears in Collections:(IC) Artículos
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