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Title

Pairing Bacteroides vulgatus LPS structure with its immunomodulatory effects on human cellular models

AuthorsDi Lorenzo, Flaviana; Pither, Molly D.; Martufi, Michela; Scarinci, Ilaria; Guzmán-Caldentey, Joan; Lakomiec, Ewelina; Jachymek, Wojciech; Bruijns, Sven C. M.; Martín-Santamaría, Sonsoles; Frick, Julia Stefanie; Van Kooyk, Yvette; Chiodo, Fabrizio; Silipo, A.; Bernardini, Maria Lina; Molinaro, Antonio
Issue Date30-Jul-2020
PublisherAmerican Chemical Society
CitationACS Cent Sci (2020)
AbstractThe gut microbiota guide the development of the host immune system by setting a systemic threshold for immune activation. Lipopolysaccharides (LPSs) from gut bacteria are able to trigger systemic and local proinflammatory and immunomodulatory responses, and this capability strongly relies on their fine structures. Up to now, only a few LPS structures from gut commensals have been elucidated; therefore, the molecular motifs that may be important for LPS–mammalian cell interactions at the gut level are still obscure. Here, we report on the full structure of the LPS isolated from one of the prominent species of the genus Bacteroides, Bacteroides vulgatus. The LPS turned out to consist of a particular chemical structure based on hypoacylated and mono-phosphorylated lipid A and with a galactofuranose-containing core oligosaccharide and an O-antigen built up of mannose and rhamnose. The evaluation of the immunological properties of this LPS on human in vitro models revealed a very interesting capability to produce anti-inflammatory cytokines and to induce a synergistic action of MD-2/TLR4- and TLR2-mediated signaling pathways.
Description15 p.-5 fig.-1 tab.-1 graph abst. This paper is dedicated to Prof. Jesús Jiménez-Barbero for his 60th birthday.
Publisher version (URL)https://doi.org/10.1021/acscentsci.0c00791
URIhttp://hdl.handle.net/10261/217456
DOI10.1021/acscentsci.0c00791
E-ISSN2374-7951
Appears in Collections:(CIB) Artículos
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