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dc.contributor.authorSudar, M.-
dc.contributor.authorFindrik, Z.-
dc.contributor.authorVasić -Rački, D.-
dc.contributor.authorSoler, Anna-
dc.contributor.authorClapés Saborit, Pere-
dc.date.accessioned2020-08-05T10:10:35Z-
dc.date.available2020-08-05T10:10:35Z-
dc.date.issued2015-
dc.identifierdoi: 10.1039/c5ra14414k-
dc.identifierissn: 2046-2069-
dc.identifier.citationRSC Advances 5: 69819- 69828 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/217453-
dc.description.abstract© The Royal Society of Chemistry 2015. A novel cascade reaction for the production of aldol adduct (3S,4R)-6-[(benzyloxycarbonyl)amino]-5,6-dideoxyhex-2-ulose was studied in this work. The strategy combines three enzymes in one pot: (i) horse liver alcohol dehydrogenase for the oxidation of N-Cbz-3-aminopropanol to the corresponding aldehyde, (ii) NADH oxidase for the regeneration of coenzyme NAD<sup>+</sup> and (iii) d-fructose-6-phosphate aldolase from E. coli A129S variant for the aldol addition of dihydroxyacetone to N-Cbz-3-aminopropanal. On the basis of preliminary experiments, optimization of the initial reaction conditions was done using statistical methods, i.e. factorial design of experiments. 79% yield of aldol adduct was achieved in the batch reactor after optimization.-
dc.languageeng-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleA new concept for production of (3S,4R)-6-[(benzyloxycarbonyl)amino]-5,6-dideoxyhex-2-ulose, a precursor of d-fagomine-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1039/c5ra14414k-
dc.relation.publisherversionhttp://dx.doi.org/10.1039/c5ra14414k-
dc.date.updated2020-08-05T10:10:36Z-
dc.relation.csic-
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