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dc.contributor.authorCulebras, Estheres_ES
dc.contributor.authorHernández, Félixes_ES
dc.date.accessioned2020-07-31T07:10:23Z-
dc.date.available2020-07-31T07:10:23Z-
dc.date.issued2020-06-24-
dc.identifier.citationEuropean Heart Journal ehaa521 (2020)es_ES
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10261/217254-
dc.description.abstractThis commentary refers to ‘Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors’, by I.E. Sama et al., 2020;41:1810–1817. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting disease termed coronavirus disease 2019 (COVID-19) shows a fatality rate greater in men compared with women.1 To explain this, some hypotheses have been raised, from genes that regulate the immune system encoded on the X chromosome to smoking behaviour,2 to expression levels1 or variants for angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV-2.3However, we would like to point out that the ACE2 gene is located on the X chromosome (location: Xp22.2; nucleotides 15 494 402–15 602 148, GRCh38.hg38 version). To our knowledge, the importance of ACE2 localization on the X chromosome has not been explored previously. Often, to have two copies ameliorates the deleterious effects of X-linked diseases and, as a consequence, most X-linked syndromes produce male diseases.es_ES
dc.description.sponsorshipFunded by Autonoma University and Hospital Clínico San Carlos (employer).es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsopenAccesses_ES
dc.titleACE2 is on the X chromosome: could this explain COVID-19 gender differences?es_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1093/eurheartj/ehaa521-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1093/eurheartj/ehaa521es_ES
dc.identifier.e-issn1522-9645-
dc.contributor.funderHospital Clínico San Carlos (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidHernández, Félix [0000-0001-8753-8249]es_ES
Appears in Collections:(CBM) Artículos
(VICYT) Colección Especial COVID-19
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