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dc.contributor.authorThomson, Timothy M.es_ES
dc.contributor.authorToscano-Guerra, Emilyes_ES
dc.contributor.authorCasis, Ernestoes_ES
dc.contributor.authorPaciucci, Rosanaes_ES
dc.date.accessioned2020-07-30T08:48:40Z-
dc.date.available2020-07-30T08:48:40Z-
dc.date.issued2020-06-12-
dc.identifier.citationBritish Journal of Haematology (2020)es_ES
dc.identifier.issn0007-1048-
dc.identifier.urihttp://hdl.handle.net/10261/217217-
dc.description.abstractCoronavirus disease 2019 (COVID‐19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life‐threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus‐2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen‐specific mechanism that may help explain significant systemic abnormalities in patients with COVID‐19.es_ES
dc.description.sponsorshipThis study was supported by grant COVID‐006 from the Spanish Science Council (CSIC) (to T.M.T.). Research by R.P. is funded by the Spanish Ministry of Science and Innovation (RTI 2018‐096055‐B‐100).es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relationMICIU/ICTI2017-2020/RTI2018-096055-B-I00es_ES
dc.relationRTI2018-096055-B-I00/AEI/10.13039/501100011033es_ES
dc.rightsopenAccesses_ES
dc.subjectContact systemes_ES
dc.subjectSerpinses_ES
dc.subjectVirology complementes_ES
dc.subjectSARS‐CoV‐2es_ES
dc.titleC1 esterase inhibitor and the contact system in COVID‐19es_ES
dc.title.alternativeC1-INH and the contact system in COVID-19es_ES
dc.typeartículoes_ES
dc.identifier.doi10.1111/bjh.16938-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1111/bjh.16938es_ES
dc.identifier.e-issn1365-2141-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.contributor.orcidThomson, Timothy M. [0000-0002-4670-9440]es_ES
dc.contributor.orcidToscano-Guerra, Emily [0000-0003-2718-1684]es_ES
dc.contributor.orcidPaciucci, Rosana [0000-0002-1087-6378]es_ES
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(VICYT) Colección Especial COVID-19
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