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Title

C1 esterase inhibitor and the contact system in COVID‐19

Other TitlesC1-INH and the contact system in COVID-19
AuthorsThomson, Timothy M. ; Toscano-Guerra, Emily; Casis, Ernesto; Paciucci, Rosana
KeywordsContact system
Serpins
Virology complement
SARS‐CoV‐2
Issue Date12-Jun-2020
PublisherJohn Wiley & Sons
CitationBritish Journal of Haematology (2020)
AbstractCoronavirus disease 2019 (COVID‐19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life‐threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus‐2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen‐specific mechanism that may help explain significant systemic abnormalities in patients with COVID‐19.
Publisher version (URL)https://doi.org/10.1111/bjh.16938
URIhttp://hdl.handle.net/10261/217217
DOI10.1111/bjh.16938
ISSN0007-1048
E-ISSN1365-2141
Appears in Collections:(IBMB) Artículos
(VICYT) Colección Especial COVID-19
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