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dc.contributor.authorPortugal, Josées_ES
dc.date.accessioned2020-07-22T19:14:57Z-
dc.date.available2020-07-22T19:14:57Z-
dc.date.issued2020-06-15-
dc.identifier.citationBiopolymers e23385 (2020)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/216918-
dc.description.abstractDespite the rise of sophisticated new targeting strategies in cancer chemotherapy, many classic DNA‐binding drugs remain on the front line of the therapy against cancer. Based on examples primarily from the author's laboratory, this article reviews the capabilities of several DNA‐binding drugs to alter gene expression. Research is ongoing about the molecular bases of the inhibition of gene expression and how alteration of the cellular transcriptome can commit cancer cells to die. The development of a variety of omic techniques allows us to gain insights into the effect of antitumor drugs. Genome‐wide approaches provide unbiased genomic data that can facilitate a deeper understanding of the cellular response to DNA‐binding drugs. Moreover, the results of large‐scale genomic studies are gathered in publicly available databases that can be used in developing precision medicine in cancer treatment.es_ES
dc.description.sponsorshipWork in the author's laboratory is supported by grant RTI2018‐096175‐B‐I00 from the Spanish Ministry of Science, Innovation and Universities, and by the Generalitat de Catalunya (2017SGR902).es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.relationMICIU/ICTI2017-2020/RTI2018-096175-B-I00es_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccessen_EN
dc.subjectCell deathes_ES
dc.subjectDNA‐drug interactionses_ES
dc.subjectTranscription factorses_ES
dc.subjectGenomicses_ES
dc.titleInsights into DNA-drug interactions in the era of omicses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1002/bip.23385-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/bip.23385es_ES
dc.embargo.terms2021-06-15es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
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