English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/216787
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Pericarditis and myocarditis long after SARS-CoV-2 infection: a cross-sectional descriptive study in health-care workers

AuthorsEiros, Rocío; Barreiro-Pérez, Manuel; Martin-Garcia, Ana; Almeida, Julia ; Villacorta, Eduardo; Pérez-Pons, Alba; Merchan, Soraya; Torres-Valle, Alba; Sanchez-Pablo, Clara; Gonzalez-Calle, David; Perez-Escurza, Oihane; Toranzo, Inés; Diaz-Pelaez, Elena; Fuentes-Herrero, Blanca; Macias-Alvarez, Laura; Oliva-Ariza, Guillermo; Lécrevisse, Quentin; Fluxá, Rafael; Bravo-Grandez, José L.; Orfao, Alberto ; Sánchez, Pedro L.
Issue Date14-Jul-2020
PublisherMedRxiv
AbstractBackground: Cardiac sequelae of past SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in health-care workers to report evidence of pericarditis and myocarditis after SARS-CoV-2 infection.
Methods We studied 139 health-care workers with confirmed past SARS-CoV-2 infection (103 diagnosed by RT-PCR and 36 by serology). Participants underwent clinical assessment, electrocardiography, laboratory tests including immune cell profiling and cardiac magnetic resonance (CMR) imaging. Pericarditis was diagnosed when classical criteria were present, and the diagnosis of myocarditis was based on the updated CMR Lake-Louise-Criteria.
Results: Median age was 52 years (IQR 41-57), 100 (72%) were women, and 23 (16%) were previously hospitalized for Covid-19 pneumonia. At examination (10.4 [9.3-11.0] weeks after infection-like symptoms), all participants presented hemodynamic stability. Chest pain, dyspnoea or palpitations were observed in 58 (42%) participants; electrocardiographic abnormalities in 69 (50%); NT-pro-BNP was elevated in 11 (8%); troponin in 1 (1%); and CMR abnormalities in 104 (75%). Isolated pericarditis was diagnosed in 4 (3%) participants, myopericarditis in 15 (11%) and isolated myocarditis in 36 (26%). Participants diagnosed by RT-PCR were more likely to still present symptoms than participants diagnosed by serology (73 [71%] vs 18 [50%]; p=0.027); nonetheless, the prevalence of pericarditis or myocarditis was high in both groups (44 [43%] vs 11 [31%]; p=0.238). Most participants (101 [73%]) showed altered immune cell counts in blood, particularly decreased eosinophil (37 [27%]; p<0.001) and increased CD4-CD8-/loT alpha beta-cell numbers (24 [17%]; p<0.001). Pericarditis was associated with elevated CD4-CD8-/loT alpha beta-cell numbers (p=0.011), while participants diagnosed with myopericarditis or myocarditis had lower (p<0.05) plasmacytoid dendritic cell, NK-cell and plasma cell counts and lower anti-SARS-CoV-2-IgG antibody levels (p=0.027).
Conclusions: Pericarditis and myocarditis with clinical stability are frequent long after SARS-CoV-2 infection, even in presently asymptomatic subjects. These observations will probably apply to the general population infected and may indicate that cardiac sequelae might occur late in association with an altered (delayed) innate and adaptative immune response.
Publisher version (URL)https://doi.org/10.1101/2020.07.12.20151316
URIhttp://hdl.handle.net/10261/216787
DOI10.1101/2020.07.12.20151316
Appears in Collections:(IBMCC) Artículos
(VICYT) Colección Especial COVID-19
Files in This Item:
File Description SizeFormat 
Pericarditis and myocarditis long after SARS_Eiros.pdf1,17 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.