English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/216779
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Synthesis of Diketopiperazine Scaffolds with Tailored N‐ and α‐Chains by Selective Modification of Customizable Units

AuthorsSaavedra, Carlos J.; Cuevas, Fernando; Romero-Estudillo, Iván; Boto, Alicia
KeywordsChemoselectivity
Domino reactions
Organic synthesis
Peptides
Sustainable chemistry
Issue Date28-May-2020
PublisherWiley-VCH
CitationAdvanced Synthesis and Catalysis 362(15): 3158-3169 (2020)
AbstractThe selective manipulation of Hyp customizable units in DKP substrates allows the generation of a rigid scaffold with four tailor‐made chains which are spatially‐orientated. The key step is a domino radical scission‐oxidation process which allows the generation of N‐substituted DKPs. The versatility of this methodology to produce scaffolds in high optical purity for material and drug discovery is described herein.
Publisher version (URL)https://doi.org/10.1002/adsc.202000470
URIhttp://hdl.handle.net/10261/216779
DOIhttp://dx.doi.org/10.1002/adsc.202000470
ISSN1615-4150
E-ISSN1615-4169
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
Synthesis-Boto-2020-ASC.pdf Embargoed until May 28, 2021Artículo principal1,72 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.