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Title

The role of the RNA-RNA interactome in the hepatitis C virus life cycle

AuthorsRomero-López, Cristina; Berzal-Herranz, Alfredo
KeywordsHCV
functional RNA domains
interactome
long-distant RNA-RNA interactions
Issue Date2020
PublisherMolecular Diversity Preservation International
CitationInternational Journal of Molecular Sciences 21 (2020)
AbstractRNA virus genomes are multifunctional entities endowed with conserved structural elements that control translation, replication and encapsidation, among other processes. The preservation of these structural RNA elements constraints the genomic sequence variability. The hepatitis C virus (HCV) genome is a positive, single-stranded RNA molecule with numerous conserved structural elements that manage different steps during the infection cycle. Their function is ensured by the association of protein factors, but also by the establishment of complex, active, long-range RNA-RNA interaction networks-the so-called HCV RNA interactome. This review describes the RNA genome functions mediated via RNA-RNA contacts, and revisits some canonical ideas regarding the role of functional high-order structures during the HCV infective cycle. By outlining the roles of long-range RNA-RNA interactions from translation to virion budding, and the functional domains involved, this work provides an overview of the HCV genome as a dynamic device that manages the course of viral infection.
Publisher version (URL)http://dx.doi.org/10.3390/ijms21041479
URIhttp://hdl.handle.net/10261/216752
Identifiersdoi: 10.3390/ijms21041479
issn: 1661-6596
e-issn: 1422-0067
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