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dc.contributor.authorGonzález-Mancebo, Daniel-
dc.contributor.authorBecerro, Ana Isabel-
dc.contributor.authorCorral, Ariadna-
dc.contributor.authorGarcía-Embid, Sonia-
dc.contributor.authorBalcerzyk, Marcin-
dc.contributor.authorGarcía-Martín, María L.-
dc.contributor.authorFuente, Jesús M. de la-
dc.contributor.authorOcaña, Manuel-
dc.date.accessioned2020-07-15T12:10:11Z-
dc.date.available2020-07-15T12:10:11Z-
dc.date.issued2020-
dc.identifierdoi: 10.1016/j.jcis.2020.03.101-
dc.identifierissn: 1095-7103-
dc.identifier.citationJournal of Colloid and Interface Science 573: 278-286 (2020)-
dc.identifier.urihttp://hdl.handle.net/10261/216703-
dc.description.abstractThe combination of different bioimaging techniques, mainly in the field of oncology, allows circumventing the defects associated with the individual imaging modalities, thus providing a more reliable diagnosis. The development of multimodal endogenous probes that are simultaneously suitable for various imaging modalities, such as magnetic resonance imaging (MRI), X-ray computed tomography (CT) and luminescent imaging (LI) is, therefore, highly recommended. Such probes should operate in the conditions imposed by the newest imaging equipment, such as MRI operating at high magnetic fields and dual-energy CT. They should show, as well, high photoluminescence emission intensity for their use in optical imaging and present good biocompatibility. In this context, we have designed a single nanoprobe, based on a core-shell architecture, composed of a luminescent Eu:BaLuF core surrounded by an external HoF shell that confers the probe with very high magnetic transverse relaxivity at high field. An intermediate, optically inert BaLuF layer was interposed between the core and the shell to hinder Eu–Ho cross-relaxation and avoid luminescence quenching. The presence of Ba and Lu, with different K-edges, allows for good X-ray attenuation at high and low voltages. The core-shell nanoparticles synthesized are good potential candidates as trimodal bioprobes for MRI at high field, dual-energy CT and luminescent imaging.-
dc.description.sponsorshipThis research was funded by the Spanish Ministry of Science, Innovation, and Universities (RTI2018-094426-B-I00). Siemens Healthcare S.L.U. also supported part of the research. We also acknowledge the use of the CNA’s ICTS NanoCT facilities and support from DGA and Fondos Feder for funding Bionanosurf (E15_17R) research group. S. Garcia-Embid acknowledges the Ministerio de Educación, Cultura y Deportes of Spanish Government for a FPU grant (FPU15/04482).-
dc.languageeng-
dc.publisherElsevier-
dc.relationMICIU/ICTI2017-2020/RTI2018-094426-B-I00-
dc.relationRTI2018-094426-B-I00/AEI/10.13039/501100011033-
dc.relation.isversionofPostprint-
dc.rightsembargoedAccess-
dc.subjectLanthanide nanoparticles-
dc.subjectTrimodal-
dc.subjectHigh field MRI-
dc.subjectDual energy CT-
dc.subjectLuminescence-
dc.titleDesign of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.jcis.2020.03.101-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jcis.2020.03.101-
dc.embargo.terms2022-04-03-
dc.date.updated2020-07-15T12:10:11Z-
dc.contributor.funderAgencia Estatal de Investigación (España)-
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España)-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderDiputación General de Aragón-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003176es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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