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Title

Crowding Induces Differences in the Diffusion of Thermophilic and Mesophilic Proteins: A New Look at Neutron Scattering Results

AuthorsMarcos, Enrique ; Mestres, Pau; Crehuet, Ramón
Issue Date2011
PublisherBiophysical Society
CitationBiophysical Journal 101: 2782- 2789 (2011)
AbstractThe dynamical basis underlying the increased thermal stability of thermophilic proteins remains uncertain. Here, we challenge the new paradigm established by neutron scattering experiments in solution, in which the adaptation of thermophilic proteins to high temperatures lies in the lower sensitivity of their flexibility to temperature changes. By means of a combination of molecular dynamics and Brownian dynamics simulations, we report a reinterpretation of those experiments and show evidence that under crowding conditions, such as in vivo, thermophilic and homolog mesophilic proteins have diffusional properties with different thermal behavior.
URIhttp://hdl.handle.net/10261/216649
Identifiersissn: 0006-3495
Appears in Collections:(IQAC) Artículos
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