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Title

CONSTANS–FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis

AuthorsSerrano-Bueno, Gloria CSIC ORCID ; Said, Fátima E. CSIC; Reyes, Pedro de los; Lucas-Reina, Eva CSIC; Ortíz-Marchena, M. Isabel CSIC; Romero, José M. ; Valverde, Federico CSIC ORCID
KeywordsFloral transition
Photoperiodic flowering
CONSTANS
Posttranslational modification
Protein stability
FKBP12
Issue Date2020
PublisherBlackwell Publishing
CitationPlant Journal 101: 1287- 1302 (2020)
AbstractFlowering time is a key process in plant development. Photoperiodic signals play a crucial role in the floral transition in Arabidopsis thaliana, and the protein CONSTANS (CO) has a central regulatory function that is tightly regulated at the transcriptional and post-translational levels. The stability of CO protein depends on a light-driven proteasome process that optimizes its accumulation in the evening to promote the production of the florigen FLOWERING LOCUS T (FT) and induce seasonal flowering. To further investigate the post-translational regulation of CO protein we have dissected its interactome network employing in vivo and in vitro assays and molecular genetics approaches. The immunophilin FKBP12 has been identified in Arabidopsis as a CO interactor that regulates its accumulation and activity. FKBP12 and CO interact through the CCT domain, affecting the stability and function of CO. fkbp12 insertion mutants show a delay in flowering time, while FKBP12 overexpression accelerates flowering, and these phenotypes can be directly related to a change in accumulation of FT protein. The interaction is conserved between the Chlamydomonas algal orthologs CrCO–CrFKBP12, revealing an ancient regulatory step in photoperiod regulation of plant development.
Publisher version (URL)http://dx.doi.org/10.1111/tpj.14590
URIhttp://hdl.handle.net/10261/216533
DOI10.1111/tpj.14590
Identifiersdoi: 10.1111/tpj.14590
issn: 1365-313X
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