English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/216260
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

The increasing impact of lethal mutagenesis of viruses

AuthorsPerales, Celia ; Gallego, Isabel ; Ávila, Ana Isabel de; Soria, María Eugenia; Gregori, Josep; Quer, Josep; Domingo, Esteban
KeywordsAntiviral drugs
Error catastrophe
Viral quasispecies
Issue Date30-Aug-2019
CitationFuture Medicinal Chemistry 11: 1645- 1657 (2019)
AbstractSelection of viral mutants resistant to compounds used in therapy is a major determinant of treatment failure, a problem akin to antibiotic resistance in bacteria. In this scenario, mutagenic base and nucleoside analogs have entered the picture because they increase the mutation rate of viral populations to levels incompatible with their survival. This antiviral strategy is termed lethal mutagenesis. It has found a major impulse with the observation that some antiviral agents, which initially were considered only inhibitors of virus multiplication, may in effect exert part of their antiviral activity through mutagenesis. Here, we review the conceptual basis of lethal mutagenesis, the evidence of virus extinction through mutagenic nucleotide analogs and prospects for application in antiviral designs.
Publisher version (URL)http://dx.doi.org/10.4155/fmc-2018-0457
URIhttp://hdl.handle.net/10261/216260
DOIhttp://dx.doi.org/10.4155/fmc-2018-0457
Identifiersdoi: 10.4155/fmc-2018-0457
issn: 1756-8927
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
DomingoE_TheIncreasingImpact.pdf300,76 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.