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The increasing impact of lethal mutagenesis of viruses

AuthorsPerales, Celia ; Gallego, Isabel ; Ávila, Ana Isabel de; Soria, María Eugenia; Gregori, Josep; Quer, Josep; Domingo, Esteban
KeywordsAntiviral drugs
Error catastrophe
Viral quasispecies
Issue Date30-Aug-2019
CitationFuture Medicinal Chemistry 11: 1645- 1657 (2019)
AbstractSelection of viral mutants resistant to compounds used in therapy is a major determinant of treatment failure, a problem akin to antibiotic resistance in bacteria. In this scenario, mutagenic base and nucleoside analogs have entered the picture because they increase the mutation rate of viral populations to levels incompatible with their survival. This antiviral strategy is termed lethal mutagenesis. It has found a major impulse with the observation that some antiviral agents, which initially were considered only inhibitors of virus multiplication, may in effect exert part of their antiviral activity through mutagenesis. Here, we review the conceptual basis of lethal mutagenesis, the evidence of virus extinction through mutagenic nucleotide analogs and prospects for application in antiviral designs.
Publisher version (URL)http://dx.doi.org/10.4155/fmc-2018-0457
Identifiersdoi: 10.4155/fmc-2018-0457
issn: 1756-8927
Appears in Collections:(CBM) Artículos
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