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Título: | The increasing impact of lethal mutagenesis of viruses |
Autor: | Perales, Celia CSIC ORCID; Gallego, Isabel CSIC ORCID; Ávila, Ana Isabel de; Soria, María Eugenia; Gregori, Josep; Quer, Josep; Domingo, Esteban CSIC ORCID | Palabras clave: | Antiviral drugs Error catastrophe Viral quasispecies |
Fecha de publicación: | 30-ago-2019 | Citación: | Future Medicinal Chemistry 11: 1645- 1657 (2019) | Resumen: | Selection of viral mutants resistant to compounds used in therapy is a major determinant of treatment failure, a problem akin to antibiotic resistance in bacteria. In this scenario, mutagenic base and nucleoside analogs have entered the picture because they increase the mutation rate of viral populations to levels incompatible with their survival. This antiviral strategy is termed lethal mutagenesis. It has found a major impulse with the observation that some antiviral agents, which initially were considered only inhibitors of virus multiplication, may in effect exert part of their antiviral activity through mutagenesis. Here, we review the conceptual basis of lethal mutagenesis, the evidence of virus extinction through mutagenic nucleotide analogs and prospects for application in antiviral designs. | Versión del editor: | http://dx.doi.org/10.4155/fmc-2018-0457 | URI: | http://hdl.handle.net/10261/216260 | DOI: | 10.4155/fmc-2018-0457 | Identificadores: | doi: 10.4155/fmc-2018-0457 issn: 1756-8927 |
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DomingoE_TheIncreasingImpact.pdf | 300,76 kB | Adobe PDF | Visualizar/Abrir |
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