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dc.contributor.authorJiménez-Martínez, Marta-
dc.contributor.authorStamatakis, Konstantinos-
dc.contributor.authorFresno, Manuel-
dc.date.accessioned2020-07-08T10:50:38Z-
dc.date.available2020-07-08T10:50:38Z-
dc.date.issued2019-04-01-
dc.identifierdoi: 10.3390/ijms20071626-
dc.identifierissn: 1422-0067-
dc.identifier.citationInternational Journal of Molecular Sciences 20(7): 1626 (2019)-
dc.identifier.urihttp://hdl.handle.net/10261/216242-
dc.description.abstractCancer is one of the most diagnosed diseases in developed countries. Inflammation is a common response to different stress situations including cancer and infection. In those processes, the family of mitogen-activated protein kinases (MAPKs) has an important role regulating cytokine secretion, proliferation, survival, and apoptosis, among others. MAPKs regulate a large number of extracellular signals upon a variety of physiological as well as pathological conditions. MAPKs activation is tightly regulated by phosphorylation/dephosphorylation events. In this regard, the dual-specificity phosphatase 10 (DUSP10) has been described as a MAPK phosphatase that negatively regulates p38 MAPK and c-Jun N-terminal kinase (JNK) in several cellular types and tissues. Several studies have proposed that extracellular signal-regulated kinase (ERK) can be also modulated by DUSP10. This suggests a complex role of DUSP10 on MAPKs regulation and, in consequence, its impact in a wide variety of responses involved in both cancer and inflammation. Here, we review DUSP10 function in cancerous and immune cells and studies in both mouse models and patients that establish a clear role of DUSP10 in different processes such as inflammation, immunity, and cancer.-
dc.description.sponsorshipMinisterio de Ciencia e Innovación (SAF2013-42850-R and SAF2016-75988-R) Comunidad de Madrid (S2017/BMD-3671. INFLAMUNE-CM), Fondo de Investigaciones Sanitarias (BIOIMID) to M.F. K.S. was recipient of a Spanish Association Against Cancer oncology investigator grant (AECC AIO)-
dc.description.sponsorshipWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International-
dc.relationS2017/BMD-3671/INFLAMUNE-CM-
dc.relationMINECO/ICTI2013-2016/SAF2013-42850-R-
dc.relationMINECO/ICTI2013-2016/SAF2016-75988-R-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectDUSP10-
dc.subjectMAPK-
dc.subjectInflammation-
dc.subjectCancer-
dc.titleThe dual-specificity phosphatase 10 (DUSP10): Its role in cancer, inflammation, and immunity-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/ijms20071626-
dc.relation.publisherversionhttp://dx.doi.org/10.3390/ijms20071626-
dc.date.updated2020-07-08T10:50:39Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderAsociación Española Contra el Cáncer-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
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