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Electrochemical Biosensors Based onMembrane-Bound Enzymes in Biomimetic Configurations

AuthorsÁlvarez-Malmagro, Julia; García-Molina, Gabriel; López de Lacey, Antonio
Biomimetic membranes
Membrane-bound enzymes
Issue Date16-Jun-2020
PublisherMolecular Diversity Preservation International
CitationSensors 2020, 20, 3393;
Abstract[EN] In nature, many enzymes are attached or inserted into the cell membrane, having hydrophobic subunits or lipid chains for this purpose. Their reconstitution on electrodes maintaining their natural structural characteristics allows for optimizing their electrocatalytic properties and stability. Different biomimetic strategies have been developed for modifying electrodes surfaces to accommodate membrane-bound enzymes, including the formation of self-assembled monolayers of hydrophobic compounds, lipid bilayers, or liposomes deposition. An overview of the different strategies used for the formation of biomimetic membranes, the reconstitution of membrane enzymes on electrodes, and their applications as biosensors is presented.
Publisher version (URL)https://doi.org/10.3390/s20123393
Appears in Collections:(ICP) Artículos
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