In vitro evaluation of leishmanicidal properties of a new family of monodimensional coordination polymers based on diclofenac ligand

Abstract

Some series of isostructural chains with general formula [M(diclof)(HO)]·(EtOH) have been obtained from reaction between diclofenac ligand (diclof) and first row transition salts (M = Mn (1),Ni (2) and Co (3)). These monodimensional coordination polymers have been characterized and their crystal structures have been solved by X-ray diffraction methods, elucidating isostructural compounds that are chains with water molecules acting as bridge between different metallic centers, while diclofenac ligands are coordinated to the octahedral coordination environment of the same. Magnetic studies of these complexes have revealed the existence of moderate ferromagnetic interactions among manganese, nickel and cobalt ions, with J values of 0.1, 0.60 and 3.3 cm, respectively. It must be highlighted that in vitro leishmanicidal activity of these new complexes has been studied against three different strains of Leishmania spp. showing a higher efficacy than the reference drug Glucantime® and demonstrating the potential of these novel materials based on coordination chemistry.