English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/215850
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


A new implication of quasispecies dynamics: Broad virus diversification in absence of external perturbations

AuthorsDomingo, Esteban ; Soria, María Eugenia; Gallego, I.; Ávila, Ana Isabel de; García-Crespo, C.; Martínez-González, Brenda; Gómez, Jordi; Briones, Carlos ; Gregori, J.; Quer, Josep; Perales, Celia
KeywordsAdaptive strategies
Foot-and-mouth disease virus
Hepatitis C virus
Mutational waves
RNA viruses
Selective forces
Issue Date2020
CitationInfection, Genetics and Evolution 82 (2020)
AbstractRNA genetic elements include many important animal and plant pathogens. They share high mutability, a trait that has multiple implications for the interactions with their host organisms. Here we review evidence of a new adaptive feature of RNA viruses that we term “broadly diversifying selection”. It constitutes a new type of positive selection without participation of any external selective agent, and which is built upon a progressive increase of the number of different genomes that dominate the population. The evidence was provided by analyses of mutant spectrum composition of two important viral pathogens, foot-and-mouth disease virus (FMDV) and hepatitis C virus (HCV) after prolonged replication in their respective cell culture environment. Despite being fueled by mutations that arise randomly and in absence of an external guiding selective force, this type of selection prepares the viral population for a response to selective forces still to occur. Since current evidence suggests that broadly diversifying selection is favored by elevated mutation rates and population sizes, it may constitute a more general behavior, relevant also to the adaptive dynamics of microbial populations and cancer cells.
Publisher version (URL)http://dx.doi.org/10.1016/j.meegid.2020.104278
Identifiersdoi: 10.1016/j.meegid.2020.104278
issn: 1567-1348
Appears in Collections:(CBM) Artículos
(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.