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Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions

AuthorsRisalde, María Ángeles; Roy, Álvaro; Bezos, Javier; Pineda, Carmen; Casal, Carmen; Díez-Guerrier, Alberto; Lopez-Villalba, Ignacio; Fernández-Manzano, Álvaro; Moreno, Inmaculada; Juan, Lucía de; Domínguez, Lucas; Gortázar, Christian
Issue Date2019
PublisherBMJ Publishing Group
CitationVeterinary Record 185(24): 759 (2019)
Abstract[Background]: There is evidence for a link between vitamin D deficiency and active tuberculosis (TB). In human beings, several trials have evaluated the role of vitamin D supplementation in TB treatment with conflicting results. However, the role of vitamin D supplementation in animal TB control has received less attention. The authors evaluated the benefit of vitamin D supplementation for preventing mycobacterial infection or reducing TB lesions (TBL) in a controlled trial with goats naturally exposed to Mycobacterium caprae. [Methods]: Two groups of goats, a vitamin D-supplemented group and a non-supplemented control group, were housed for 10 months in direct contact with M caprae-infected adult goats. Upon contact with the infected adult goats, all animals were TB-tested every two months. [Results]: No experimental evidence of a protective effect of vitamin D supplementation based on M caprae culture prevalence, TBL prevalence, median TBL score or the proportion of single versus multiple organs presenting TBL was observed. [Conclusion]: The results indicate that, in the conditions used in this study, vitamin D supplementation in goats does not reduce TB infection risk nor the diffusion and severity of TBL. In addition, vitamin D-supplemented goats presented hyperphosphataemia and renal injury with calcifications suggestive of vitamin D intoxication.
Publisher version (URL)https://doi.org/10.1136/vr.105411
Identifiersdoi: 10.1136/vr.105411
issn: 0042-4900
e-issn: 2042-7670
Appears in Collections:(IREC) Artículos
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