Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/215725
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Serrano-Quílez, Joan | - |
dc.contributor.author | Roig-Soucase, Sergi | - |
dc.contributor.author | Rodríguez-Navarro, Susana | - |
dc.date.accessioned | 2020-06-30T16:46:56Z | - |
dc.date.available | 2020-06-30T16:46:56Z | - |
dc.date.issued | 2020-06-25 | - |
dc.identifier.citation | International Journal of Molecular Sciences 21(12): 4510 (2020) | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10261/215725 | - |
dc.description | © 2020 by the authors. | - |
dc.description.abstract | Meiosis is a specialized cell division that gives raise to four haploid gametes from a single diploid cell. During meiosis, homologous recombination is crucial to ensure genetic diversity and guarantee accurate chromosome segregation. Both the formation of programmed meiotic DNA double-strand breaks (DSBs) and their repair using homologous chromosomes are essential and highly regulated pathways. Similar to other processes that take place in the context of chromatin, histone posttranslational modifications (PTMs) constitute one of the major mechanisms to regulate meiotic recombination. In this review, we focus on specific PTMs occurring in histone tails as driving forces of different molecular events, including meiotic recombination and transcription. In particular, we concentrate on the influence of H3K4me3, H2BK123ub, and their corresponding molecular machineries that write, read, and erase these histone marks. The Spp1 subunit within the Complex of Proteins Associated with Set1 (COMPASS) is a critical regulator of H3K4me3-dependent meiotic DSB formation. On the other hand, the PAF1c (RNA polymerase II associated factor 1 complex) drives the ubiquitination of H2BK123 by Rad6-Bre1. We also discuss emerging evidence obtained by cryo-electron microscopy (EM) structure determination that has provided new insights into how the “cross-talk” between these two marks is accomplished. | - |
dc.description.sponsorship | This research was funded by MICIIN, Spain, grant number PGC2018-099872-B-I00. The APC was funded by MICIIN (PGC2018-099872-B-I00). J.S-Q. was funded by the FPU (Formación de Profesorado Universitario) programme (MICIIN, FPU15/03862). | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-099872-B-100 | - |
dc.relation | PGC2018-099872-B-100/AEI/10.13039/501100011033 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Meiosis | - |
dc.subject | Recombination | - |
dc.subject | DSB | - |
dc.subject | Transcription | - |
dc.subject | COMPASS | - |
dc.subject | Histone | - |
dc.subject | PAF1c | - |
dc.subject | Methylation | - |
dc.subject | Ubiquitination | - |
dc.title | Sharing Marks: H3K4 Methylation and H2B Ubiquitination as Features of Meiotic Recombination and Transcription | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/ijms21124510 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/ijms21124510 | - |
dc.identifier.e-issn | 1422-0067 | - |
dc.date.updated | 2020-06-30T16:46:57Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.pmid | 32630409 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
Aparece en las colecciones: | (IBV) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Sharing_Serrano_Quilez_Art2020.pdf | 2,33 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 15-abr-2024
SCOPUSTM
Citations
11
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
8
checked on 25-feb-2024
Page view(s)
129
checked on 17-abr-2024
Download(s)
134
checked on 17-abr-2024