English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/215725
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Sharing Marks: H3K4 Methylation and H2B Ubiquitination as Features of Meiotic Recombination and Transcription

AuthorsSerrano-Quílez, Joan; Roig-Soucase, Sergi; Rodríguez-Navarro, Susana
KeywordsMeiosis
Recombination
DSB
Transcription
COMPASS
Histone
PAF1c
Methylation
Ubiquitination
Issue Date25-Jun-2020
PublisherMultidisciplinary Digital Publishing Institute
CitationInternational Journal of Molecular Sciences 21(12): 4510 (2020)
AbstractMeiosis is a specialized cell division that gives raise to four haploid gametes from a single diploid cell. During meiosis, homologous recombination is crucial to ensure genetic diversity and guarantee accurate chromosome segregation. Both the formation of programmed meiotic DNA double-strand breaks (DSBs) and their repair using homologous chromosomes are essential and highly regulated pathways. Similar to other processes that take place in the context of chromatin, histone posttranslational modifications (PTMs) constitute one of the major mechanisms to regulate meiotic recombination. In this review, we focus on specific PTMs occurring in histone tails as driving forces of different molecular events, including meiotic recombination and transcription. In particular, we concentrate on the influence of H3K4me3, H2BK123ub, and their corresponding molecular machineries that write, read, and erase these histone marks. The Spp1 subunit within the Complex of Proteins Associated with Set1 (COMPASS) is a critical regulator of H3K4me3-dependent meiotic DSB formation. On the other hand, the PAF1c (RNA polymerase II associated factor 1 complex) drives the ubiquitination of H2BK123 by Rad6-Bre1. We also discuss emerging evidence obtained by cryo-electron microscopy (EM) structure determination that has provided new insights into how the “cross-talk” between these two marks is accomplished.
Description© 2020 by the authors.
Publisher version (URL)https://doi.org/10.3390/ijms21124510
URIhttp://hdl.handle.net/10261/215725
DOI10.3390/ijms21124510
ISSN1661-6596
E-ISSN1422-0067
Appears in Collections:(IBV) Artículos
Files in This Item:
File Description SizeFormat 
Sharing_Serrano_Quilez_Art2020.pdf2,33 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.