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dc.contributor.authorGonzález-Mancha, Natalia-
dc.contributor.authorMérida, Isabel-
dc.date.accessioned2020-06-30T16:45:52Z-
dc.date.available2020-06-30T16:45:52Z-
dc.date.issued2020-06-15-
dc.identifier.citationInternational Journal of Molecular Sciences 21(12): 4254 (2020)-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10261/215720-
dc.description© 2020 by the authors.-
dc.description.abstractRecognition of antigens displayed on the surface of an antigen-presenting cell (APC) by T-cell receptors (TCR) of a T lymphocyte leads to the formation of a specialized contact between both cells named the immune synapse (IS). This highly organized structure ensures cell–cell communication and sustained T-cell activation. An essential lipid regulating T-cell activation is diacylglycerol (DAG), which accumulates at the cell–cell interface and mediates recruitment and activation of proteins involved in signaling and polarization. Formation of the IS requires rearrangement of the cytoskeleton, translocation of the microtubule-organizing center (MTOC) and vesicular compartments, and reorganization of signaling and adhesion molecules within the cell–cell junction. Among the multiple players involved in this polarized intracellular trafficking, we find sorting nexin 27 (SNX27). This protein translocates to the T cell–APC interface upon TCR activation, and it is suggested to facilitate the transport of cargoes toward this structure. Furthermore, its interaction with diacylglycerol kinase ζ (DGKζ), a negative regulator of DAG, sustains the precise modulation of this lipid and, thus, facilitates IS organization and signaling. Here, we review the role of SNX27, DAG metabolism, and their interplay in the control of T-cell activation and establishment of the IS.-
dc.description.sponsorshipThe work of Natalia González-Mancha received funding from the European Union Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 713673 and “La Caixa” Foundation (ID 100010434). The fellowship code is LCF/BQ/DI17/11620027. Research in Merida’s lab is funded by grants from the Spanish Association Against Cancer (AECC, CICPF18), Aplastic Anemia and MDS International Foundation (AAMDSIF, OPE01644), Spanish Ministry Economy and Competitiveness co-financed by the European Regional Development Fund (BFU2016-77207-R), and the Madrid regional government (IMMUNOTHERCAM Consortium S2010/BMD-2326) to I.M.-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/713673-
dc.relationMINECO/ICTI2013-2016/BFU2016-77207-R-
dc.relation.isversionofPublisher’s version-
dc.rightsopenAccess-
dc.subjectDiacylglycerol-
dc.subjectDiacylglycerol kinase-
dc.subjectSNX27-
dc.subjectRetromer-
dc.subjectImmune synapse-
dc.subjectIntracellular trafficking-
dc.titleInterplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/ijms21124254-
dc.description.peerreviewedPeer reviewed-
dc.relation.publisherversionhttps://doi.org/10.3390/ijms21124254-
dc.identifier.e-issn1422-0067-
dc.date.updated2020-06-30T16:45:53Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderObra Social la Caixa-
dc.contributor.funderAsociación Española Contra el Cáncer-
dc.contributor.funderComunidad de Madrid-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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