English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/215720
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS

AuthorsGonzález-Mancha, Natalia; Mérida, Isabel
KeywordsDiacylglycerol
Diacylglycerol kinase
SNX27
Retromer
Immune synapse
Intracellular trafficking
Issue Date15-Jun-2020
PublisherMultidisciplinary Digital Publishing Institute
CitationInternational Journal of Molecular Sciences 21(12): 4254 (2020)
AbstractRecognition of antigens displayed on the surface of an antigen-presenting cell (APC) by T-cell receptors (TCR) of a T lymphocyte leads to the formation of a specialized contact between both cells named the immune synapse (IS). This highly organized structure ensures cell–cell communication and sustained T-cell activation. An essential lipid regulating T-cell activation is diacylglycerol (DAG), which accumulates at the cell–cell interface and mediates recruitment and activation of proteins involved in signaling and polarization. Formation of the IS requires rearrangement of the cytoskeleton, translocation of the microtubule-organizing center (MTOC) and vesicular compartments, and reorganization of signaling and adhesion molecules within the cell–cell junction. Among the multiple players involved in this polarized intracellular trafficking, we find sorting nexin 27 (SNX27). This protein translocates to the T cell–APC interface upon TCR activation, and it is suggested to facilitate the transport of cargoes toward this structure. Furthermore, its interaction with diacylglycerol kinase ζ (DGKζ), a negative regulator of DAG, sustains the precise modulation of this lipid and, thus, facilitates IS organization and signaling. Here, we review the role of SNX27, DAG metabolism, and their interplay in the control of T-cell activation and establishment of the IS.
Description© 2020 by the authors.
Publisher version (URL)https://doi.org/10.3390/ijms21124254
URIhttp://hdl.handle.net/10261/215720
DOIhttp://dx.doi.org/10.3390/ijms21124254
ISSN1661-6596
E-ISSN1422-0067
Appears in Collections:(CNB) Artículos
Files in This Item:
File Description SizeFormat 
Interplay_González_Mancha_Art2020.pdf1,76 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.