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dc.contributor.author | Cruz-Chamorro, Iván | - |
dc.contributor.author | Álvarez Sánchez, Nuria | - |
dc.contributor.author | Santos-Sánchez, Guillermo | - |
dc.contributor.author | Pedroche, Justo | - |
dc.contributor.author | Fernández-Pachón, María Soledad | - |
dc.contributor.author | Millán, Francisco | - |
dc.contributor.author | Millán-Linares, María del Carmen | - |
dc.contributor.author | Lardone, Patricia Judith | - |
dc.contributor.author | Bejarano, Ignacio | - |
dc.contributor.author | Guerrero Montávez, Juan Miguel | - |
dc.contributor.author | Carrillo-Vico, Antonio | - |
dc.date.accessioned | 2020-06-30T16:42:53Z | - |
dc.date.available | 2020-06-30T16:42:53Z | - |
dc.date.issued | 2020-06-04 | - |
dc.identifier.citation | Nutrients 12(6): 1673 (2020) | - |
dc.identifier.uri | http://hdl.handle.net/10261/215704 | - |
dc.description.abstract | Peptides from several plant food proteins not only maintain the nutritional values of the original protein and decrease the environmental impact of animal agriculture, but also exert biological activities with significant health-beneficial effects. Wheat is the most important food grain source in the world. However, negative attention on wheat-based products has arose due to the role of gluten in celiac disease. A controlled enzymatic hydrolysis could reduce the antigenicity of wheat gluten protein hydrolysates (WGPHs). Therefore, the aims of the present study were to evaluate the effects of the in vitro administration of Alcalase-generated WGPHs on the immunological and antioxidant responses of human peripheral blood mononuclear cells (PBMCs) from 39 healthy subjects. WGPH treatment reduced cell proliferation and the production of the Type 1 T helper (Th1) and Th17 pro-inflammatory cytokines IFN-γ and IL-17, respectively. WPGHs also improved the cellular anti-inflammatory microenvironment, increasing Th2/Th1 and Th2/Th17 balances. Additionally, WGPHs improved global antioxidant capacity, increased levels of the reduced form of glutathione and reduced nitric oxide production. These findings, not previously reported, highlight the beneficial capacity of these vegetable protein hydrolysates, which might represent an effective alternative in functional food generation. | - |
dc.description.sponsorship | This work was supported by the Spanish Government, Ministerio de Economía y Competitividad (AGL2012-40247-C02-01 and AGL2012-40247-C02-02) the Andalusian Government Ministry of Health (PC-0111-2016-0111) and the PAIDI Program from the Andalusian Government (CTS160). I.C.-C. was supported by Ministerio de Economía y Competitividad (AGL2012-40247-C02-02) and by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU13/01210). N.Á.-S. was supported by Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (RD06/0013/0001 and RD12/0043/0012). G.S.-S. was supported by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/02339). I.B. was supported by the VI Program of Inner Initiative for Research and Transfer of University of Seville (VI PPIT-US). | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.rights | openAccess | - |
dc.subject | wheat gluten protein hydrolysates | - |
dc.subject | Bioactive peptides | - |
dc.subject | pro-inflammatory cytokines | - |
dc.subject | oxidative stress | - |
dc.subject | Antioxidant capacity | - |
dc.subject | Glutathione | - |
dc.subject | peripheral blood mononuclear cells | - |
dc.title | Immunomodulatory and antioxidant properties of wheat gluten protein hydrolysates in human peripheral blood mononuclear cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/nu12061673 | - |
dc.relation.publisherversion | https://doi.org/10.3390/nu12061673 | - |
dc.identifier.e-issn | 2072-6643 | - |
dc.date.updated | 2020-06-30T16:42:53Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Universidad de Sevilla | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100009042 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 32512720 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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immunomodulatory_antioxidant_wheat_gluten.pdf | 1,17 MB | Adobe PDF | Visualizar/Abrir |
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