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dc.contributor.authorFontecha, F. Javier-
dc.contributor.authorBrink, Lauren-
dc.contributor.authorWu, Steven-
dc.contributor.authorPouliot, Yves-
dc.contributor.authorVisioli, Francesco-
dc.contributor.authorJiménez-Flores, Rafael-
dc.date.accessioned2020-06-30T16:42:42Z-
dc.date.available2020-06-30T16:42:42Z-
dc.date.issued2020-05-30-
dc.identifier.citationNutrients 12(6): 1607 (2020)-
dc.identifier.issn2072-6643-
dc.identifier.urihttp://hdl.handle.net/10261/215703-
dc.descriptionThis article belongs to the Special Issue Breastmilk as a Model: Efforts to Improve Infant Formulae for Term Infants.-
dc.description.abstractResearch on milk fat globule membrane (MFGM) is gaining traction. The interest is two-fold; on the one hand, it is a unique trilayer structure with specific secretory function. On the other hand, it is the basis for ingredients with the presence of phospho- and sphingolipids and glycoproteins, which are being used as food ingredients with valuable functionality, in particular, for use as a supplement in infant nutrition. This last application is at the center of this Review, which aims to contribute to understanding MFGM’s function in the proper development of immunity, cognition, and intestinal trophism, in addition to other potential effects such as prevention of diseases including cardiovascular disease, impaired bone turnover and inflammation, skin conditions, and infections as well as age-associated cognitive decline and muscle loss. The phospholipid composition of MFGM from bovine milk is quite like human milk and, although there are some differences due to dairy processing, these do not result in a chemical change. The MFGM ingredients, as used to improve the formulation in different clinical studies, have indeed increased the presence of phospholipids, sphingolipids, glycolipids, and glycoproteins with the resulting benefits of different outcomes (especially immune and cognitive outcomes) with no reported adverse effects. Nevertheless, the precise mechanism(s) of action of MFGM remain to be elucidated and further basic investigation is warranted.-
dc.description.sponsorshipThis study was carried out within the framework of the AGL2017-87884 Project (MINECO/AEI/FEDER, UE). J.F. gratefully acknowledges support from the Spanish Fulbright Program for his stay as a visiting scholar and the hospitality of Dr. Jimenez-Flores at FST (OSU, OH).-
dc.language.isoeng-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relationMICIU/ICTI2017-2020/AGL2017-87884-R-
dc.relationAGL2017-87884-R/AEI/10.13039/501100011033-
dc.relation.isversionofPublisher’s version-
dc.rightsopenAccess-
dc.subjectMilk fat globule membrane-
dc.subjectPolar lipid composition-
dc.subjectSources-
dc.subjectProduction-
dc.subjectClinical studies-
dc.subjectInfant nutrition-
dc.subjectInfant formula-
dc.titleSources, production, and clinical treatments of milk fat globule membrane for infant nutrition and well-being-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/nu12061607-
dc.description.peerreviewedPeer reviewed-
dc.relation.publisherversionhttps://doi.org/10.3390/nu12061607-
dc.identifier.e-issn2072-6643-
dc.date.updated2020-06-30T16:42:43Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)-
dc.contributor.funderAgencia Estatal de Investigación (España)-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
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