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Title

Brain NMDA Receptors in Schizophrenia and Depression

AuthorsAdell, Albert
KeywordsNMDA
Depression
Schizophrenia
Subunit
Glutamate
GABA
Issue Date23-Jun-2020
PublisherMultidisciplinary Digital Publishing Institute
CitationBiomolecules 10(6): 947 (2020)
AbstractN-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP), dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia, both in animals and humans. However, ketamine has been recently approved for treatment-resistant depression, although with severe restrictions. Interestingly, the dosage in both conditions is similar, and positive symptoms of schizophrenia appear before antidepressant effects emerge. Here, we describe the temporal mechanisms implicated in schizophrenia-like and antidepressant-like effects of NMDA blockade in rats, and postulate that such effects may indicate that NMDA receptor antagonists induce similar mechanistic effects, and only the basal pre-drug state of the organism delimitates the overall outcome. Hence, blockade of NMDA receptors in depressive-like status can lead to amelioration or remission of symptoms, whereas healthy individuals develop psychotic symptoms and schizophrenia patients show an exacerbation of these symptoms after the administration of NMDA receptor antagonists.
Description© 2020 by the author.
Publisher version (URL)https://doi.org/10.3390/biom10060947
URIhttp://hdl.handle.net/10261/215648
DOIhttp://dx.doi.org/10.3390/biom10060947
ISSN2218-273X
E-ISSN2218-273X
Appears in Collections:(IBBTEC) Artículos
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