English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/215544
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Neurosporaxanthin Overproduction by Fusarium fujikuroi and Evaluation of Its Antioxidant Properties

AuthorsParra-Rivero, Obdulia; Paes-de Barros, Marcelo; Prado, María del Mar; Gil, José Vicente ; Hornero-Méndez, Dámaso ; Zacarías, Lorenzo ; Rodrigi, María J.; Limón, M. Carmen; Ávalos, Javier
KeywordsCarotenoids
Xanthophylls
Free radicals
Oxidative stress
Fungi
Quenching
Liposomes
Issue Date16-Jun-2020
PublisherMultidisciplinary Digital Publishing Institute
CitationAntioxidants 9 (6): 528 (2020)
AbstractNeurosporaxanthin (NX) is a carboxylic carotenoid produced by some filamentous fungi, including species of the genera Neurospora and Fusarium. NX biosynthetic genes and their regulation have been thoroughly investigated in Fusarium fujikuroi, an industrial fungus used for gibberellin production. In this species, carotenoid-overproducing mutants, affected in the regulatory gene carS, exhibit an upregulated expression of the NX pathway. Based on former data on a stimulatory effect of nitrogen starvation on carotenoid biosynthesis, we developed culture conditions with carS mutants allowing the production of deep-pigmented mycelia. With this method, we obtained samples with ca. 8 mg NX/g dry mass, in turn the highest concentration for this carotenoid described so far. NX-rich extracts obtained from these samples were used in parallel with carS-complemented NX-poor extracts obtained under the same conditions, to check the antioxidant properties of this carotenoid in in vitro assays. NX-rich extracts exhibited higher antioxidant capacity than NX-poor extracts, either when considering their quenching activity against [O2(1Δg)] in organic solvent (singlet oxygen absorption capacity (SOAC) assays) or their scavenging activity against different free radicals in aqueous solution and in liposomes. These results make NX a promising carotenoid as a possible feed or food additive, and encourage further studies on its chemical properties.
Description17 Páginas.-- 5 Figuras
Publisher version (URL)http://dx.doi.org/10.3390/antiox9060528
URIhttp://hdl.handle.net/10261/215544
E-ISSN2076-3921
Appears in Collections:(IG) Artículos
Files in This Item:
File Description SizeFormat 
antioxidants_09_00528_v2.pdfArtículo principal1,97 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.