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dc.contributor.authorCartwright, Julyan H. E.-
dc.contributor.authorPiro, Oreste-
dc.contributor.authorTuval, Idan-
dc.date.accessioned2020-06-29T11:10:13Z-
dc.date.available2020-06-29T11:10:13Z-
dc.date.issued2020-02-17-
dc.identifierdoi: 10.1098/rstb.2019.0566-
dc.identifierissn: 1471-2970-
dc.identifier.citationPhilosophical Transactions - B - Biological Sciences 375(1792): 20190566 (2020)-
dc.identifier.urihttp://hdl.handle.net/10261/215480-
dc.description.abstractHow is sensing carried out by cilia in the mouse node, zebrafish Kupffer's vesicle and similar left-right (LR) organizer organs in other species? Two possibilities have been put forward. In the former, cilia would detect some chemical species in the fluid; in the latter, they would detect fluid flow. In either case, the hypothesis is that an imbalance would be detected between this signalling coming from cilia on the left and right sides of the organizer, which would initiate a cascade of signals leading ultimately to the breaking of LR symmetry in the developing body plan of the organism. We review the evidence for both hypotheses.-
dc.description.sponsorshipWe acknowledge the financial support of the Spanish MINCINN project FIS2016-77692-C2.-
dc.languageeng-
dc.publisherRoyal Society (Great Britain)-
dc.relationMINECO/ICTI2013-2016/FIS2016-77692-C2-
dc.rightsclosedAccess-
dc.subjectChemosensing-
dc.subjectKupffer's vesicle-
dc.subjectLeft-right organizer-
dc.subjectMechanosensing-
dc.subjectNode-
dc.subjectPrimary cilia-
dc.titleChemosensing versus mechanosensing in nodal and Kupffer's vesicle cilia and in other left-right organizer organs-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1098/rstb.2019.0566-
dc.relation.publisherversionhttp://dx.doi.org/10.1098/rstb.2019.0566-
dc.date.updated2020-06-29T11:10:14Z-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
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