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Title

Chemosensing versus mechanosensing in nodal and Kupffer's vesicle cilia and in other left-right organizer organs

AuthorsCartwright, Julyan H. E. ; Piro, Oreste ; Tuval, Idan
KeywordsChemosensing
Kupffer's vesicle
Left-right organizer
Mechanosensing
Node
Primary cilia
Issue Date23-Oct-2019
PublisherRoyal Society (Great Britain)
CitationPhilosophical Transactions - B - Biological Sciences 375(2020)
AbstractHow is sensing carried out by cilia in the mouse node, zebrafish Kupffer's vesicle and similar left-right (LR) organizer organs in other species? Two possibilities have been put forward. In the former, cilia would detect some chemical species in the fluid; in the latter, they would detect fluid flow. In either case, the hypothesis is that an imbalance would be detected between this signalling coming from cilia on the left and right sides of the organizer, which would initiate a cascade of signals leading ultimately to the breaking of LR symmetry in the developing body plan of the organism. We review the evidence for both hypotheses.
Publisher version (URL)http://dx.doi.org/10.1098/rstb.2019.0566
URIhttp://hdl.handle.net/10261/215480
Identifiersdoi: 10.1098/rstb.2019.0566
issn: 1471-2970
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(IACT) Artículos
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