English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/215475
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Carvacrol prodrugs with antimicrobial activity loaded on clay nanocomposites

AuthorsEusepi, Piera; Marinelli , Lisa; García-Villén, Fátima; Borrego Sánchez, Ana CSIC ORCID; Cacciatore, Ivana; Di Stefano, Antonio; Viseras, César
Issue Date10-Apr-2020
PublisherMultidisciplinary Digital Publishing Institute
CitationMaterials 13 (7): 1793 (2020)
AbstractBackground: Carvacrol, an essential oil with antimicrobial activity against a wide range of pathogens, and its water soluble carvacrol prodrugs (WSCP1-3) were intercalated into montmorillonite (VHS) interlayers to improve their stability in physiological media and promote their absorption in the intestine. Methods: Intercalation of prodrugs by cation exchange with montmorillonite interlayer counterions was verified by X-ray powder diffraction and confirmed by Fourier transform infrared spectroscopy and thermal analysis. Results: In vitro release studies demonstrated that montmorillonite successfully controlled the release of the adsorbed prodrugs and promoted their bioactivation only in the intestinal tract where carvacrol could develop its maximum antimicrobial activity. The amount of WSCP1, WSCP2, and WSCP3 released from VHS were 38%, 54%, and 45% at acid pH in 120 min, and 65%, 78%, and 44% at pH 6.8 in 240 min, respectively. Conclusions: The resultant hybrids successfully controlled conversion of the prodrugs to carvacrol, avoiding premature degradation of the drug.
Publisher version (URL)http://dx.doi.org/10.3390/MA13071793
Identifiersdoi: 10.3390/MA13071793
issn: 1996-1944
Appears in Collections:(IACT) Artículos
Files in This Item:
File Description SizeFormat 
Viseras_C_Minerals13_1793.pdf1,15 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.