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http://hdl.handle.net/10261/215348
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Thomas, Jobin | es_ES |
dc.contributor.author | Infantes-Lorenzo, José Antonio | es_ES |
dc.contributor.author | Moreno, Inmaculada | es_ES |
dc.contributor.author | Romero, Beatriz | es_ES |
dc.contributor.author | Garrido, Joseba M. | es_ES |
dc.contributor.author | Juste, Ramón A. | es_ES |
dc.contributor.author | Domínguez, Lucas | es_ES |
dc.contributor.author | Gortázar, Christian | es_ES |
dc.contributor.author | Risalde, María Ángeles | es_ES |
dc.date.accessioned | 2020-06-26T07:51:24Z | - |
dc.date.available | 2020-06-26T07:51:24Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Veterinary Journal 244: 98-103 (2019) | es_ES |
dc.identifier.issn | 1090-0233 | - |
dc.identifier.uri | http://hdl.handle.net/10261/215348 | - |
dc.description | Preliminary results were presented as a Poster at XXII Simposio, Avedila, Valladolid, 16–17 November 2017. | es_ES |
dc.description.abstract | Red deer (Cervus elaphus) farming is a growing economic activity worldwide. However, the capacity of this species to act as reservoir of animal tuberculosis (TB) poses a threat to other wildlife and to livestock. Diagnostic assay accuracy in this species is therefore highly relevant for prevention and control measures. Our aim was to evaluate the diagnostic performance of the protein complex P22, obtained from Mycobacterium bovis derived purified protein derivative (bPPD), as a candidate antigen for the detection of antibodies against Mycobacterium tuberculosis complex (MTC). We assessed the performance of this new antigen in indirect enzyme-linked immunosorbent assays (ELISA) in TB-positive and TB-negative red deer, in comparison with a bPPD-based ELISA. The P22 ELISA achieved a higher specificity (Sp) and similar sensitivity (Se) in comparison with the bPPD ELISA at all the cut-off points considered. The P22 ELISA yielded optimal Sp (99.02%; 95% confidence intervals [CI95%]: 96.5–99.8) and appropriate Se (70.1%; CI95%: 63.6–76) at the selected cut-off point of 100%. These results suggest that P22 can be used as an alternative antigen in the immunodiagnosis of animal TB through the use of an ELISA-type detection of antibodies against MTC in red deer, thus contributing to the diagnosis of animal TB in this species as a measure for further disease prevention and control programs. | es_ES |
dc.description.sponsorship | Research funding was provided by ‘Plan Nacional’ grant AGL2014-56305 (MINECO, Spain and FEDER). J. Thomas was supported by a grant from the Indian Council of Agricultural Research-International Fellowship 2014-15 (ICAR-IF 2014-15). J.A. Infantes was supported by a FPU contract-fellowship (FPU2013/6000) (Ministry of Education, Culture and Sport, Spain). M.A. Risalde holds a ‘Juan de la Cierva program’ contract (IJCI-2014-19961) (Ministry of Economy and Competitiveness, Spain). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/IJCI-2014-19961 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-56305-C3-1-R | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Bovine PPD | es_ES |
dc.subject | Cervids | es_ES |
dc.subject | Serology | es_ES |
dc.subject | Tuberculosis diagnosis | es_ES |
dc.title | A new test to detect antibodies against Mycobacterium tuberculosis complex in red deer serum | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.tvjl.2018.12.021 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.tvjl.2018.12.021 | es_ES |
dc.identifier.e-issn | 1532-2971 | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Indian Council of Agricultural Research | es_ES |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001503 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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