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Prostaglandin F2α-induced Prostate Transmembrane Protein, Androgen Induced 1 mediates ovarian cancer progression increasing epithelial plasticity

AutorJiménez-Segovia, Alba; Mota, Alba CSIC ORCID; Rojo-Sebastian, Alejandro; Barrocal, Beatriz; Rynne-Vidal, Ángela; García-Bermejo, María Laura; Gómez-Bris, Raquel; Hawinkels, Lukas J. A. C.; Sandoval, Pilar CSIC ORCID; García-Escudero, Ramón CSIC ORCID; López-Cabrera, Manuel; Moreno-Bueno, Gema CSIC ORCID; Fresno, Manuel CSIC ORCID ; Stamatakis, Konstantinos CSIC ORCID
Fecha de publicación2019
CitaciónNeoplasia (New York, N.Y.) 21: 1073- 1084 (2019)
ResumenThe role of prostaglandin (PG) F has been scarcely studied in cancer. We have identified a new function for PGF in ovarian cancer, stimulating the production of Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1). We show that this induction increases cell plasticity and proliferation, enhancing tumor growth through PMEPA1. Thus, PMEPA1 overexpression in ovarian carcinoma cells, significantly increased cell proliferation rates, whereas PMEPA1 silencing decreased proliferation. In addition, PMEPA1 overexpression buffered TGFβ signaling, via reduction of SMAD-dependent signaling. PMEPA1 overexpressing cells acquired an epithelial morphology, associated with higher E-cadherin expression levels while β-catenin nuclear translocation was inhibited. Notwithstanding, high PMEPA1 levels also correlated with epithelial to mesenchymal transition markers, such as vimentin and ZEB1, allowing the cells to take advantage of both epithelial and mesenchymal characteristics, gaining in cell plasticity and adaptability. Interestingly, in mouse xenografts, PMEPA1 overexpressing ovarian cells had a clear survival and proliferative advantage, resulting in higher metastatic capacity, while PMEPA1 silencing had the opposite effect. Furthermore, high PMEPA1 expression in a cohort of advanced ovarian cancer patients was observed, correlating with E-cadherin expression. Most importantly, high PMEPA1 mRNA levels were associated with lower patient survival.
Versión del editorhttp://dx.doi.org/10.1016/j.neo.2019.10.001
URIhttp://hdl.handle.net/10261/215277
DOI10.1016/j.neo.2019.10.001
Identificadoresdoi: 10.1016/j.neo.2019.10.001
issn: 1476-5586
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