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Nucleus–cytoplasm cross-talk in the aging brain

AuthorsBenvegnú, Stefano
Amyotrophic lateral sclerosis
Alzheimer's disease
Frontotemporal dementia
Huntington disease
Neurodegenerative diseases
Prion diseases
Issue Date2019
PublisherJohn Wiley & Sons
CitationJournal of Neuroscience Research (2019)
AbstractAging is a primary risk factor for fatal neurodegenerative disorders, yet the mechanisms underlying physiological healthy aging and pathological aging, and how these mechanisms can divert one scenario to the other, are not completely understood. In recent years, reports indicate that alterations in nucleocytoplasmic transport may be a hallmark of both healthy and pathological aging. In this review, I summarize recent evidence supporting this information, specifically focusing on the association between the nucleocytoplasmic transport and aging of the brain, indicating both common and case-specific mechanisms and their interplay, and pointing out alterations of these mechanisms as regulatory “switches” for the fate of the aging brain. Importantly, some of these alterations are intervenable druggable targets, paving the way to a future pharmacotherapeutic intervention.
Publisher version (URL)http://dx.doi.org/10.1002/jnr.24446
Identifiersdoi: 10.1002/jnr.24446
issn: 1097-4547
Appears in Collections:(CBM) Artículos
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