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dc.contributor.authorRamos-Sevillano, Elisaes_ES
dc.contributor.authorUrzainqui, Anaes_ES
dc.contributor.authorMoscoso, Miriames_ES
dc.contributor.authorSánchez-Madrid, Franciscoes_ES
dc.contributor.authorBrown, Jeremy S.es_ES
dc.contributor.authorGarcía, Ernestoes_ES
dc.contributor.authorYuste, Josées_ES
dc.date.accessioned2020-06-24T09:50:25Z-
dc.date.available2020-06-24T09:50:25Z-
dc.date.issued2013-05-
dc.identifier.citationXI European Meeting on the Molecular Biology of the Pneumococcus (EuroPneumo 2013)es_ES
dc.identifier.isbn978-84-88754-51-6-
dc.identifier.urihttp://hdl.handle.net/10261/215101-
dc.description2 p.es_ES
dc.description.abstractLeukocytes play an important role in inflammatory and immune responses. Clear-ance of the bacterium depends on the efficacy of different receptors on the surface of phagocytic cells to recognize, internalize and kill the pathogen [1]. Phagocyto-sis of Streptococcus pneumoniae was greatly enhanced in the absence of pneumo-lysin and LytA demonstrating a synergistic effect by both proteins in host immune response evasion. A novel interaction with the P-selectin glycoprotein ligand-1 receptor (PSGL-1) of neutrophils was observed, with a significant involvement of Ply and LytA in this process. Moreover, bacterial levels were significantly in-creased in PSGL-1–/– knockout mice confirming the importance of this receptor in the recognition and clearance of S. pneumoniae.es_ES
dc.language.isoenges_ES
dc.publisherFundación General de la Universidad de Alcaláes_ES
dc.publisherInstituto de Salud Carlos III (España)es_ES
dc.publisherCSIC - Instituto de Química Física Rocasolano (IQFR)es_ES
dc.publisherCSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectPhagocytosises_ES
dc.subjectNeutrophilses_ES
dc.subjectPSGL-1es_ES
dc.subjectMicees_ES
dc.titlePneumolysin and LytA avoid phagocytosis by alveolar macrophages and neutrophils and enhance invasive diseasees_ES
dc.typecomunicación de congresoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://europneumo2013.iqfr.csic.es/EP-2013-Program-and-Abstracts-Book.pdfes_ES
dc.contributor.funderPfizeres_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/100004319es_ES
dc.contributor.orcidRamos-Sevillano, Elisa [0000-0003-0803-2755]es_ES
dc.contributor.orcidUrzainqui, Ana [0000-0001-9326-6112]es_ES
dc.contributor.orcidMoscoso, Miriam [0000-0001-8977-3269]es_ES
dc.contributor.orcidSánchez-Madrid, Francisco [0000-0001-5303-0762]es_ES
dc.contributor.orcidBrown, Jeremy S. [0000-0002-5650-5361]es_ES
dc.contributor.orcidGarcía, Ernesto [0000-0002-1741-5486]es_ES
dc.contributor.orcidYuste, José [0000-0001-7996-0837]es_ES
Appears in Collections:(CIB) Comunicaciones congresos
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