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Pneumolysin and LytA avoid phagocytosis by alveolar macrophages and neutrophils and enhance invasive disease

AuthorsRamos-Sevillano, Elisa ; Urzainqui, Ana; Moscoso, Miriam ; Sánchez-Madrid, Francisco; Brown, Jeremy S.; García, Ernesto ; Yuste, José
Issue DateMay-2013
PublisherFundación General de la Universidad de Alcalá
Instituto de Salud Carlos III (España)
CSIC - Instituto de Química Física Rocasolano (IQFR)
CSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
CitationXI European Meeting on the Molecular Biology of the Pneumococcus (EuroPneumo 2013)
AbstractLeukocytes play an important role in inflammatory and immune responses. Clear-ance of the bacterium depends on the efficacy of different receptors on the surface of phagocytic cells to recognize, internalize and kill the pathogen [1]. Phagocyto-sis of Streptococcus pneumoniae was greatly enhanced in the absence of pneumo-lysin and LytA demonstrating a synergistic effect by both proteins in host immune response evasion. A novel interaction with the P-selectin glycoprotein ligand-1 receptor (PSGL-1) of neutrophils was observed, with a significant involvement of Ply and LytA in this process. Moreover, bacterial levels were significantly in-creased in PSGL-1–/– knockout mice confirming the importance of this receptor in the recognition and clearance of S. pneumoniae.
Description2 p.
Publisher version (URL)http://europneumo2013.iqfr.csic.es/EP-2013-Program-and-Abstracts-Book.pdf
Appears in Collections:(CIB) Comunicaciones congresos
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