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dc.contributor.authorGómez Morales, Jaime-
dc.contributor.authorVerdugo Escamilla, Cristóbal-
dc.contributor.authorFernández Penas, Raquel-
dc.contributor.authorParra MIlla, Carmen María-
dc.contributor.authorDrouet, Christophe-
dc.contributor.authorMaube-Bosc, Françoise-
dc.contributor.authorOltolina, Francesca-
dc.contributor.authorPrat, Maria-
dc.contributor.authorFernández Sánchez, Jorge Fernando-
dc.identifierdoi: 10.1039/c7ra12536d-
dc.identifierissn: 2046-2069-
dc.identifier.citationRSC Advances 8: 2385-2397 (2018)-
dc.description.abstractNanomedicine covers the application of nanotechnologies in medicine. Of particular interest is the setup of highly-cytocompatible nanoparticles for use as drug carriers and/or for medical imaging. In this context, luminescent nanoparticles are appealing nanodevices with great potential for imaging of tumor or other targetable cells, and several strategies are under investigation. Biomimetic apatite nanoparticles represent candidates of choice in nanomedicine due to their high intrinsic biocompatibility and to the highly accommodative properties of the apatite structure, allowing many ionic substitutions. In this work, the preparation of biomimetic (bone-like) citrate-coated carbonated apatite nanoparticles doped with europium ions is explored using the citrate-based thermal decomplexing approach. The technique allows the preparation of the single apatitic phase with nanosized dimensions only at Eu doping concentrations ≤0.01 M at some timepoints. The presence of the citrate coating on the particle surface (as found in bone nanoapatites) and Eu substituting Ca is beneficial for the preparation of stable suspensions at physiological pH, as witnessed by the ζ-potential versus pH characterizations. The sensitized luminescence features of the solid particles, as a function of the Eu doping concentrations and the maturation times, have been thoroughly investigated, while those of particles in suspensions have been investigated at different pHs, ionic strengths and temperatures. Their cytocompatibility is illustrated in vitro on two selected cell types, the GTL-16 human carcinoma cells and the m17.ASC murine mesenchymal stem cells. This contribution shows the potentiality of the thermal decomplexing method for the setup of luminescent biomimetic apatite nanoprobes with controlled features for use in bioimaging.-
dc.description.sponsorshipWe greatly acknowledge the project Biomin-nanoapatite MAT2014-60533-R supported by Spanish MINEICO and co-funded by FEDER and the Excellence Network of Crystallography and Crystallization “Factoría de Cristalización” FIS2015-71928-REDC supported by Spanish MINEICO. Cristóbal Verdugo-Escamilla also acknowledges the Spanish MINEICO for his contract PTA2015-11103-I.-
dc.publisherRoyal Society of Chemistry (UK)-
dc.relation.isversionofPublisher's version-
dc.titleLuminescent biomimetic citrate-coated europium-doped carbonated apatite nanoparticles for use in bioimaging: Physico-chemistry and cytocompatibility-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderEuropean Commission-
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