English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/214796
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Luminescent biomimetic citrate-coated europium-doped carbonated apatite nanoparticles for use in bioimaging: Physico-chemistry and cytocompatibility

AuthorsGómez Morales, Jaime; Verdugo Escamilla, Cristóbal ; Fernández Penas, Raquel; Parra MIlla, Carmen María; Drouet, Christophe; Maube-Bosc, Françoise; Oltolina, Francesca; Prat, Maria; Fernández Sánchez, Jorge Fernando
Issue Date10-Jan-2018
PublisherRoyal Society of Chemistry (UK)
CitationRSC Advances 8: 2385-2397 (2018)
AbstractNanomedicine covers the application of nanotechnologies in medicine. Of particular interest is the setup of highly-cytocompatible nanoparticles for use as drug carriers and/or for medical imaging. In this context, luminescent nanoparticles are appealing nanodevices with great potential for imaging of tumor or other targetable cells, and several strategies are under investigation. Biomimetic apatite nanoparticles represent candidates of choice in nanomedicine due to their high intrinsic biocompatibility and to the highly accommodative properties of the apatite structure, allowing many ionic substitutions. In this work, the preparation of biomimetic (bone-like) citrate-coated carbonated apatite nanoparticles doped with europium ions is explored using the citrate-based thermal decomplexing approach. The technique allows the preparation of the single apatitic phase with nanosized dimensions only at Eu doping concentrations ≤0.01 M at some timepoints. The presence of the citrate coating on the particle surface (as found in bone nanoapatites) and Eu substituting Ca is beneficial for the preparation of stable suspensions at physiological pH, as witnessed by the ζ-potential versus pH characterizations. The sensitized luminescence features of the solid particles, as a function of the Eu doping concentrations and the maturation times, have been thoroughly investigated, while those of particles in suspensions have been investigated at different pHs, ionic strengths and temperatures. Their cytocompatibility is illustrated in vitro on two selected cell types, the GTL-16 human carcinoma cells and the m17.ASC murine mesenchymal stem cells. This contribution shows the potentiality of the thermal decomplexing method for the setup of luminescent biomimetic apatite nanoprobes with controlled features for use in bioimaging.
Publisher version (URL)http://dx.doi.org/10.1039/c7ra12536d
URIhttp://hdl.handle.net/10261/214796
Identifiersdoi: 10.1039/c7ra12536d
issn: 2046-2069
Appears in Collections:(IACT) Artículos
Files in This Item:
File Description SizeFormat 
Jaime_Gomez_RSCAdv8_2385.pdf1,88 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.