English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/214721
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Multi-omic Analysis of Zebrafish Models of Acute Organophosphorus Poisoning With Different Severity

AuthorsPiña, Benjamín ; Ziv, Tamar; Faria, Melissa ; Ben-Lulu, Shani; Prats, Eva ; Arick, Mark A; Gómez-Canela, Cristian ; García-Reyero, Natàlia; Admon, Arie; Raldúa, Demetrio
KeywordsAnimal models
Zebrafish
Acute organophosphorus poisoning
Multiomics
Issue DateJun-2019
PublisherOxford University Press
CitationToxicological Sciences 171 (1): 211-220 (2019)
AbstractOrganophosphorus compounds are acetylcholinesterase inhibitors used as pesticides and chemical warfare nerve agents. Acute organophosphorus poisoning (acute OPP) affects 3 million people, with 300 000 deaths annually worldwide. Severe acute OPP effects include overstimulation of cholinergic neurons, seizures, status epilepticus, and finally, brain damage. In a previous study, we developed 3 different chemical models of acute OPP in zebrafish larvae. To elucidate the complex pathophysiological pathways related to acute OPP, we used integrative omics (proteomic, transcriptomics, and metabolomics) on these 3 animal models. Our results show that these stochastic, apparently disparate morphological phenotypes can result from almost linear concentration-response variations in molecular levels. Results from the multiomics analysis strongly suggest that endoplasmic reticulum stress might play a central role in the pathophysiology of severe acute OPP, emphasizing the urgent need of further research on this molecular pathway. Endoplasmic reticulum stress could be an important therapeutic target to be included in the treatment of patients with severe acute OPP.
Publisher version (URL)https://doi.org/10.1093/toxsci/kfz133
URIhttp://hdl.handle.net/10261/214721
DOI10.1093/toxsci/kfz133
Appears in Collections:(IDAEA) Artículos
Files in This Item:
File Description SizeFormat 
CPO multiomic final version_Toxicol Sciv2BP.docxArtículo principal125,75 kBMicrosoft Word XMLView/Open
Supplementary Figure S1.tiffMaterial suplementario8,8 MBTIFFThumbnail
View/Open
Figure 1.tiffImágenes8,8 MBTIFFThumbnail
View/Open
Figure 2.tiffImágenes8,8 MBTIFFThumbnail
View/Open
Figure 3.tiffImágenes8,8 MBTIFFThumbnail
View/Open
Figure 4A.tiffImágenes13,68 MBTIFFThumbnail
View/Open
Figure 4B.tiffImágenes8,8 MBTIFFThumbnail
View/Open
SUPPLEMENTARY DATA.pdfMaterial suplementario460 kBAdobe PDFThumbnail
View/Open
TableS1.xlsxTablas30,61 kBMicrosoft Excel XMLView/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.