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dc.contributor.authorBoya, Patriciaes_ES
dc.contributor.authorRamírez-Pardo, Ignacioes_ES
dc.contributor.authorVillarejo-Zori, Beatrizes_ES
dc.contributor.authorGómez-Sintes, Raqueles_ES
dc.identifier.citationInvestigative Ophthalmology & Visual Science 61 (2020)es_ES
dc.descriptionAbstract from 2020 ARVO Annual Meeting, canceled because of COVID-19es_ES
dc.description.abstractPurpose : Ambra1 (activating-molecule in Beclin-1-regulated autophagy) is a protein that regulates the early stages of autophagy initiation. Ambra1 haploinsufficiency is linked to autophagy under several pathological conditions such as Alzheimer Disease, autism or multiple system atrophy. In the retina, there is a decline in the autophagy response upon ageing thus we aimed to test if Ambragt/+ haploinsufficiency might affect retinal ageing.es_ES
dc.description.abstractMethods : As Ambra1 homozigous animals are embryonic lethal, we have analised the phenotype of Ambra1gt/+ during aging and compared with Ambra1+/+ litermates. We have assessed retinal morphology and function with ERG in animals up to 24 months as well as compared the metabolic profile using mass spectrometry.es_ES
dc.description.abstractResults : Our results show that Ambra1gt/+ display premature death in comparison to control littermates. We also observe symptoms of premature retinal ageing in Ambra1gt/+ mice at 15 months old. This tendency was increased in geriatric animals (>20 months) as Ambra1gt/+ displayed increased inflammatory response and a reduction in the photoreceptor layer thickness. Finally, aged Ambra1gt/+ mice displayed a different metabolic signature indicating a misbalance in the purine metabolism and redox status.es_ES
dc.description.abstractConclusions : This data suggest that autophagy deficiency results in a pro-ageing phenotype and impair retinal homeostasis and metabolism.es_ES
dc.publisherAssociation for Research in Vision and Ophthalmologyes_ES
dc.titleAmbra1 and its role during physiological ageing in the retinaes_ES
dc.typecomunicación de congresoes_ES
dc.description.peerreviewedPeer reviewedes_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidBoya, Patricia [0000-0003-3045-951X]es_ES
dc.contributor.orcidGómez-Sintes, Raquel [0000-0003-2854-6964]es_ES
Appears in Collections:(CIB) Comunicaciones congresos
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