English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/214648
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Extracellular monomeric tau is internalized by astrocytes

AuthorsPerea, Juan Ramón; López, Esther; Díez-Ballesteros, José C.; Ávila, Jesús ; Hernández, Félix; Bolós, Marta
KeywordsTau Tauopathies
Astrocytes
Heparan sulfate proteoglycans
Internalization
Propagation
Issue Date1-May-2019
CitationFrontiers in Neuroscience 13 (2019)
AbstractTau is a microtubule-associated protein that is expressed in neurons. However, in a group of neurodegenerative diseases named tauopathies-characterized by an increase in aggregated and/or hyperphosphorylated Tau-the protein accumulates inside other cells, such as astrocytes and microglia. Given that these glial cells do not produce Tau, its presence can be explained by internalization from the extracellular medium and consequent formation of Tau aggregates. Among internalization mechanisms, heparan sulfate proteoglycans (HSPGs) have been proposed to be responsible for fibrillary Tau uptake in various cell types. Here we studied whether monomeric Tau, which has been observed to be internalized by glial cells such as microglia, was also taken up by astrocytes. Although this Tau form was internalized from the extracellular medium by these cells, the mechanism of uptake was found to be independent of HSPGs.
Publisher version (URL)http://dx.doi.org/10.3389/fnins.2019.00442
URIhttp://hdl.handle.net/10261/214648
DOIhttp://dx.doi.org/10.3389/fnins.2019.00442
Identifiersdoi: 10.3389/fnins.2019.00442
issn: 1662-453X
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
HernándezF_ExtracellularMonomeric.pdf1,67 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.