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Título: | Candidemia in solid organ transplant recipients in Spain: Epidemiological trends and determinants of outcome |
Autor: | Fernández‐Ruiz, Mario; Cardozo, Celia; Salavert, Miguel; Aguilar Guisado, Manuela CSIC ORCID; Escolà‐Vergé, Laura; Muñoz, Patricia; Gioia, Francesca; Montejo, Miguel; Merino, Paloma; Cuervo, Guillermo; García‐Vidal, Carolina; Aguado, José María | Palabras clave: | Candidemia Epidemiology Outcome Solid organ transplantation Treatment |
Fecha de publicación: | dic-2019 | Editor: | John Wiley & Sons | Citación: | Transplant Infectious Disease 21(6): e13195 (2019) | Resumen: | [Background] Despite being considered a high‐risk population for invasive fungal disease, specific features of candidemia among solid organ transplant (SOT) recipients remain poorly characterized. [Methods] We compiled prospective data from two multicenter studies on candidemia performed over two consecutive periods in Spain: the CANDIPOP Study (2010‐2011) and the CANDI‐Bundle Study (2016‐2018). Episodes diagnosed in adult SOT recipients in 10 participating centers were included. Risk factors for clinical failure (all‐cause 7‐day mortality and/or persistent candidemia for ≥72 hours) and 30‐day mortality were investigated by univariate analysis. [Results] We included 55 episodes of post‐transplant candidemia (32 and 23 of which occurred during the first and second periods). Kidney (38.2%) and liver recipients (30.9%) were the most common populations. Candida albicans accounted for 27.3% of episodes. The proportion of C glabrata increased over time (18.8% vs 30.4% for the first and second periods). There were no differences in the rate of fluconazole non‐susceptible isolates (50.0% vs 60.0%, respectively). Clinical failure and 30‐day mortality occurred in 25.5% and 27.3% of episodes and were associated with the severity of candidemia (Pitt score and severe sepsis/septic shock). Kidney transplantation (unadjusted odds ratio [uOR]: 0.17; 95% confidence interval [CI]: 0.03‐0.85; P ‐value = .020), early catheter removal (uOR: 0.15; 95% CI: 0.03‐0.76; P ‐value = .013), and appropriate early antifungal therapy (uOR: 0.14; 95% CI: 0.02‐0.89; P ‐value = .041) were protective for 30‐day mortality. [Conclusions] High rates of non‐albicans species and fluconazole non‐susceptibility must be taken into account to optimize therapeutic management and outcomes in SOT recipients with candidemia. |
Descripción: | CANDIPOP Project, the CANDI‐Bundle Group GEIRAS‐GEMICOMED (SEIMC) REIPI. | Versión del editor: | http://dx.doi.org/10.1111/tid.13195 | URI: | http://hdl.handle.net/10261/214644 | DOI: | 10.1111/tid.13195 | Identificadores: | doi: 10.1111/tid.13195 issn: 1398-2273 e-issn: 1399-3062 |
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