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http://hdl.handle.net/10261/214519
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Campos-Sánchez, Elena | - |
dc.contributor.author | Martínez-Cano, Jorge | - |
dc.contributor.author | Pino Molina, Lucía del | - |
dc.contributor.author | López-Granados, Eduardo | - |
dc.contributor.author | Cobaleda, César | - |
dc.date.accessioned | 2020-06-16T10:26:35Z | - |
dc.date.available | 2020-06-16T10:26:35Z | - |
dc.date.issued | 2019 | - |
dc.identifier | doi: 10.1016/j.it.2018.11.005 | - |
dc.identifier | issn: 1471-4981 | - |
dc.identifier.citation | Trends in Immunology 40: 49- 65 (2019) | - |
dc.identifier.uri | http://hdl.handle.net/10261/214519 | - |
dc.description.abstract | Primary immunodeficiencies (PIDs) are immune disorders resulting from defects in genes involved in immune regulation, and manifesting as an increased susceptibility to infections, autoimmunity, and cancer. However, the molecular basis of some prevalent entities remains poorly understood. Epigenetic control is essential for immune functions, and epigenetic alterations have been identified in different PIDs, including syndromes such as immunodeficiency-centromeric-instability-facial-anomalies, Kabuki, or Wolf–Hirschhorn, among others. Although the epigenetic changes may differ among these PIDs, the reversibility of epigenetic modifications suggests that they might become potential therapeutic targets. Here, we review recent mechanistic advances in our understanding of epigenetic alterations associated with certain PIDs, propose that a fully epigenetically driven mechanism might underlie some PIDs, and discuss the possible prophylactic and therapeutic implications. | - |
dc.description.sponsorship | FEDER, the ‘Fondo de Investigaciones Sanitarias/Instituto de Salud Carlos III’ (PI14/ 00025), MINECO (SAF2017-83061-R), the ‘Fundación Ramón Areces’, the ‘Federación Española de Enfermedades Raras’, the ‘Asociación Muévete por los que no Pueden’, and a Research Contract with the ‘Fundación Síndrome de Wolf- Hirschhorn o 4p-’. Institutional grants from the ‘Fundación Ramón Areces’ and ‘Banco de Santander’ to the CBMSO | - |
dc.language | eng | - |
dc.publisher | Elsevier BV | - |
dc.rights | openAccess | - |
dc.title | Epigenetic Deregulation in Human Primary Immunodeficiencies | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.it.2018.11.005 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.it.2018.11.005 | - |
dc.date.updated | 2020-06-16T10:26:35Z | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Federación Española de Enfermedades Raras | - |
dc.contributor.funder | Asociación Muévete por los que no Pueden | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.contributor.funder | Banco Santander | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002924 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100010784 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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CobaledaC_EpigeneticDeregulation.pdf | 2,93 MB | Adobe PDF | Visualizar/Abrir |
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