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Title

Epigenetic Deregulation in Human Primary Immunodeficiencies

AuthorsCampos-Sánchez, Elena ; Martínez-Cano, Jorge; Pino Molina, Lucía del; López-Granados, Eduardo; Cobaleda, César
Issue Date2019
PublisherElsevier BV
CitationTrends in Immunology 40: 49- 65 (2019)
AbstractPrimary immunodeficiencies (PIDs) are immune disorders resulting from defects in genes involved in immune regulation, and manifesting as an increased susceptibility to infections, autoimmunity, and cancer. However, the molecular basis of some prevalent entities remains poorly understood. Epigenetic control is essential for immune functions, and epigenetic alterations have been identified in different PIDs, including syndromes such as immunodeficiency-centromeric-instability-facial-anomalies, Kabuki, or Wolf–Hirschhorn, among others. Although the epigenetic changes may differ among these PIDs, the reversibility of epigenetic modifications suggests that they might become potential therapeutic targets. Here, we review recent mechanistic advances in our understanding of epigenetic alterations associated with certain PIDs, propose that a fully epigenetically driven mechanism might underlie some PIDs, and discuss the possible prophylactic and therapeutic implications.
Publisher version (URL)http://dx.doi.org/10.1016/j.it.2018.11.005
URIhttp://hdl.handle.net/10261/214519
Identifiersdoi: 10.1016/j.it.2018.11.005
issn: 1471-4981
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