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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Simon, Eléanor | - |
dc.contributor.author | Puebla, Sergio F. de la | - |
dc.contributor.author | Guerrero, Isabel | - |
dc.date.accessioned | 2020-06-16T09:32:03Z | - |
dc.date.available | 2020-06-16T09:32:03Z | - |
dc.date.issued | 2019-11-12 | - |
dc.identifier | doi: 10.1098/rsob.190245 | - |
dc.identifier | issn: 2046-2441 | - |
dc.identifier.citation | Open Biology 9 (2019) | - |
dc.identifier.uri | http://hdl.handle.net/10261/214487 | - |
dc.description.abstract | Specific neuropeptides regulate in arthropods the shedding of the old cuticle (ecdysis) followed by maturation of the new cuticle. In Drosophila melanogaster, the last ecdysis occurs at eclosion from the pupal case, with a post-eclosion behavioural sequence that leads to wing extension, cuticle stretching and tanning. These events are highly stereotyped and are controlled by a subset of crustacean cardioactive peptide (CCAP) neurons through the expression of the neuropeptide Bursicon (Burs). We have studied the role of the transcription factor Odd-paired (Opa) during the post-eclosion period. We report that opa is expressed in the CCAP neurons of the central nervous system during various steps of the ecdysis process and in peripheral CCAP neurons innerving the larval muscles involved in adult ecdysis. We show that its downregulation alters Burs expression in the CCAP neurons. Ectopic expression of Opa, or the vertebrate homologue Zic2, in the CCAP neurons also affects Burs expression, indicating an evolutionary functional conservation. Finally, our results show that, independently of its role in Burs regulation, Opa prevents death of CCAP neurons during larval development. | - |
dc.language | eng | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Drosophila Zic family member odd-paired is needed for adult post-ecdysis maturation | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1098/rsob.190245 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1098/rsob.190245 | - |
dc.date.updated | 2020-06-16T09:32:04Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.relation.csic | Sí | - |
dc.identifier.pmid | 31847787 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Fichero | Descripción | Tamaño | Formato | |
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GuerreroI_DrosophilaZicFamilyMember.pdf | 1,99 MB | Adobe PDF | Visualizar/Abrir |
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