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Insights into the evolutionary relationships of lytA autolysin and ply pneumolysin-like genes in Streptococcus pneumoniae and related Streptococci

AuthorsMorales, María ; Martín-Galiano, Antonio J.; Domenech, Mirian ; García, Ernesto
Main autolysin
Streptococci of the Mitis group
Genomic island
Issue Date8-Sep-2015
PublisherOxford University Press
CitationGenome Biol Evol 7(9) 2747-2761 (2015)
AbstractStreptococcus pneumoniae (pneumococcus) is amajor human pathogen. Themain pneumococcal autolysin LytA and the pneumolysin Ply are two of the bacterium’s most important virulence factors. The lytA- and ply-related genes are also found in other streptococci of the Mitis group (SMG). The precise characteristics of the lytA-related—but not the ply-related—genes of SMG and their prophages have been previously described. A search of the more than 400SMG genomic sequences available in public databases (ca. 300 for S. pneumoniae), showed Streptococcus pseudopneumoniae IS7493 to harbor four ply-related genes, two of which (plyA and plyB) have 98%identical nucleotides. The plyA homolog of S. pseudopneumoniae is conserved in all S. pneumoniae strains,and seems to be included in a pathogenicity island together with the lytA gene. However, only nonencapsulated S. pneumoniae strains possess a plyB gene,which is part of an integrative and conjugative element. Notably, the existence of a bacterial lytA-related gene in a genome is linked to the presence of plyA and vice versa. The present analysis also shows there are eight main types of plyA-lytA genomic islands. A possible stepwise scenario for the evolution of the plyA-lytA island in S. pneumoniae is proposed.
Description15 p.-8 fig.-1 tab.
Publisher version (URL)https://doi.org/10.1093/gbe/evv178
Appears in Collections:(CIB) Artículos
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