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Cascading g-C3N4 and Peroxygenases for Selective Oxyfunctionalization Reactions

AuthorsVan-Schie, Morten; Zhang, Wuyuan; Tieves, Florian; Choi, D.S.; Park, C.B.; Burek, B.O.; Bloh, Jonathan Z.; Arends, I.W.C.E.; Paul, C.E.; Alcalde Galeote, Miguel ; Hollmann, Frank
KeywordsCascade reactions
Enzyme catalysis
Issue Date2019
PublisherAmerican Chemical Society
CitationACS Catalysis 9: 7409- 7417 (2019)
Abstract[EN] Peroxygenases are very interesting catalysts for specific oxyfunctionalization chemistry. Instead of relying on complicated electron transport chains, they rely on simple hydrogen peroxide as the stoichiometric oxidant. Their poor robustness against HO can be addressed via in situ generation of HO. Here we report that simple graphitic carbon nitride (g-CN) is a promising photocatalyst to drive peroxygenase-catalyzed hydroxylation reactions. The system has been characterized by outlining not only its scope but also its current limitations. In particular, spatial separation of the photocatalyst from the enzyme is shown as a solution to circumvent the undesired inactivation of the biocatalyst. Overall, very promising turnover numbers of the biocatalyst of more than 60.000 have been achieved.
Publisher version (URL)http://dx.doi.org/10.1021/acscatal.9b01341
Identifiersdoi: 10.1021/acscatal.9b01341
issn: 2155-5435
Appears in Collections:(ICP) Artículos
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