Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/214424
COMPARTIR / EXPORTAR:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorTraore, A.-
dc.contributor.authorEllis-Gibbings, L.-
dc.contributor.authorKrupa, K.-
dc.contributor.authorLozano, Ana I.-
dc.contributor.authorColmenares, R.-
dc.contributor.authorMuñoz, A.-
dc.contributor.authorOller, J.C.-
dc.contributor.authorBlanco, F.-
dc.contributor.authorGarcía-Grande, Aránzazu-
dc.contributor.authorCoronado, M.J.-
dc.contributor.authorRosado, S.-
dc.contributor.authorRami, E.-
dc.contributor.authorNúñez, L.-
dc.contributor.authorLimão-Vieira, P.-
dc.contributor.authorGarcía, Gustavo-
dc.date.accessioned2020-06-15T13:54:55Z-
dc.date.available2020-06-15T13:54:55Z-
dc.date.issued2019-09-22-
dc.identifierdoi: https://doi.org/10.1007/978-3-030-28247-9_14-
dc.identifierisbn: 978-3-030-28246-2-
dc.identifier.citationRadiation in Bioanalysis, Spectroscopic Techniques and Theoretical Methods: 367-397 (2019)-
dc.identifier.urihttp://hdl.handle.net/10261/214424-
dc.descriptionPart of the Bioanalysis book series (BIOANALYSIS, volume 8)-
dc.description.abstractIn this study we present a modelling procedure that combines the standard electromagnetic physics of Geant4 for photons with the LEPTS event by event Monte Carlo simulation programme for secondary electrons. LEPTS provides detailed information of the energy deposition and the type and number of collision events taking place in a 1 m3 liquid water phantom when irradiated with 6 MV photons generated by a LINAC accelerator. The simulation is compared to a radiobiological experiment determining the biological effects (cell cycle alteration, early apoptosis, DNA damage) induced by the 6 MeV CLINAC radiation to a Jurkat T lymphocyte culture in a water phantom. Notable cell cycle alterations were found between 24 and 48 h after a 2 Gy radiation dose. Early apoptosis and DNA fragmentation has been analysed at 48, 72 and 96 h post irradiation. As expected, the sequence of the apoptotic process has been clear in the irradiated area up to 48 h after radiation. However, substantial apoptotic cells have also been identified outside of this area, in the penumbra and even in the low dose area, where a maximum in the percentage of DNA fragmentation is shown. We attributed this effect to the fact that although the average energy of primary and secondary particles in these areas is lower than those in the irradiated area, their interaction cross sections are much higher, thereby increasing the probability of producing damage.-
dc.description.sponsorshipThis study has been mainly supported by the EU through the FP7-PEOPLE-2013-ITN programme (project ARGENT-608163). It has also been supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (project FIS2016-80440). We also acknowledge the Hospital Universitario Puerta de Hierro of Madrid for providing the required equipment and services to perform the presented experiments.-
dc.languageeng-
dc.publisherSpringer Nature-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/608163-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2016-80440-P-
dc.relation.isversionofPostprint-
dc.rightsopenAccessen_EN
dc.titleRadiobiological Effects Induced by X-ray (LINAC) Irradiation: Experiments and Modelling-
dc.typecapítulo de libro-
dc.identifier.doi10.1007/978-3-030-28247-9_14-
dc.relation.publisherversionhttps://doi.org/10.1007/978-3-030-28247-9_14-
dc.date.updated2020-06-15T13:54:56Z-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderInstituto de Investigación Sanitaria Puerta de Hierro-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_3248es_ES
item.openairetypecapítulo de libro-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
Aparece en las colecciones: (CFMAC-IFF) Libros y partes de libros
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Radiobiological effects.pdf1,62 MBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

Page view(s)

157
checked on 28-mar-2024

Download(s)

76
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.