English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/214249
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Homocysteine and C-Reactive Protein Levels Are Associated With Frailty in Older Spaniards: The Toledo Study for Healthy Aging

AuthorsÁlvarez Sánchez, Nuria; Álvarez-Ríos, A. I.; Guerrero, Juan Miguel; García-García, Francisco José; Rodríguez-Mañas, Leocadio; Cruz-Chamorro, Iván; Lardone, Patricia Judith; Carrillo-Vico, Antonio
KeywordsPrefrailty
Fried’s criteria
Inflammation
Biochemical markers
Issue Date23-Jul-2019
PublisherOxford University Press
CitationJournals of Gerontology A - Biological Sciences and Medical Sciences XX(XX): 1-7 (2019)
AbstractHigh-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) are inflammation markers but are also related to cardiovascular diseases, disability, or higher risk of death. Although inflammation is considered to be associated with frailty, data regarding the association between hsCRP or Hcy and frailty are controversial or scarce, especially with respect to their association with prefrailty. Thus, our objective was to study the association of hsCRP and Hcy with prefrailty and frailty in 1,211 Spanish men and women aged 65â 98 years from the Toledo Study for Healthy Aging (TSHA) cohort, classified according to Friedâ s criteria. Hcy was independently associated with frailty (odds ratio [OR] = 1.06; 95% confidence interval [CI]: 1.01â 1.12), whereas hsCRP was independently associated with both prefrailty (OR = 1.03; 95% CI: 1.01â 1.06) and frailty (OR = 1.07; 95% CI: 1.02â 1.12). Furthermore, both markers were positively correlated with the number of Friedâ s criteria that were met and were independently associated with the criteria of exhaustion (Hcy: OR = 1.03, 95% CI: 1.00â 1.06), weakness (hsCRP: OR = 1.03, 95% CI: 1.01â 1.05), and low physical activity (hsCRP: OR = 1.04, 95% CI: 1.02â 1.06). Thus, our results highlight the importance of inflammation in age-related physical decline and, in particular, its association with fatigue, low strength, and decreased physical activity.
Publisher version (URL)http://dx.doi.org/10.1093/gerona/glz168
URIhttp://hdl.handle.net/10261/214249
ISSN1079-5006
E-ISSN1758-535X
Identifiersdoi: 10.1093/gerona/glz168
Appears in Collections:(IBIS) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.