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Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

AuthorsShin, Mi-Kyung; Kim, Lenise J.; Caballero-Eraso, Candela; Polotsky, Vsevolod Y.
Issue Date2019
PublisherMYJoVE Corporation
MYJoVE Corporation
CitationJournal of Visualized Experiments 152: e60298 (2019)
AbstractOur study focuses on the effects of leptin signaling in carotid body (CB) on the hypoxic ventilatory response (HVR). We performed 'loss of function' experiments measuring the effect of leptin on HVR after CB denervation and 'gain of function' experiments measuring HVR after overexpression of the leptin receptor in CB.
Publisher version (URL)http://dx.doi.org/10.3791/60298
Identifiersdoi: 10.3791/60298
e-issn: 1940-087X
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